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The transmission/disequilibrium test and parental-genotype reconstruction: the reconstruction-combined transmission/ disequilibrium test
- Publication Year :
- 1999
-
Abstract
- SummarySpielman and Ewens recently proposed a method for testing a marker for linkage with a disease, which combines data from families with and without information on parental genotypes. For some families without parental-genotype information, it may be possible to reconstruct missing parental genotypes from the genotypes of their offspring. The treatment of such a reconstructed family as if parental genotypes have been typed, however, can introduce bias. In the present study, a new method is presented that employs parental-genotype reconstruction and corrects for the biases resulting from reconstruction. The results of an application of this method to a real data set and of a simulation study suggest that this approach may increase the power to detect linkage.
- Subjects :
- Linkage disequilibrium
Genotype
Genetic Linkage
Statistics as Topic
Biology
Genetic linkage
Statistics
Genetics
Humans
Statistical analysis
Genetics(clinical)
Letters to the Editor
Genotype reconstruction
Genetics (clinical)
Linkage (software)
Models, Statistical
Transmission/disequilibrium test
Models, Genetic
Transmission disequilibrium test
Pedigree
Data set
Power analysis
Linkage analysis
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f8076e8314d651e07185ed14e9dfd0f7