Back to Search
Start Over
Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2
- Source :
- Enright, J M, Toomey, M B, Sato, S, Temple, S, Allen, J R, Fujiwara, R, Kramlinger, V M, Nagy, L D, Johnson, K M, Xiao, Y, How, M, Johnson, S L, Roberts, N, Kefalov, V J, Guengerich, P & Corbo, J 2015, ' Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting Vitamin A 1 into A 2 ', Current Biology, vol. 25, no. 23, pp. 3048-3057 . https://doi.org/10.1016/j.cub.2015.10.018
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Some vertebrate species have evolved means of extending their visual sensitivity beyond the range of human vision. One mechanism of enhancing sensitivity to long-wavelength light is to replace the 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal. Despite over a century of research on this topic, the enzymatic basis of this perceptual switch remains unknown. Here, we show that a cytochrome P450 family member, Cyp27c1, mediates this switch by converting vitamin A1 (the precursor of 11-cis retinal) into vitamin A2 (the precursor of 11-cis 3,4-didehydroretinal). Knockout of cyp27c1 in zebrafish abrogates production of vitamin A2, eliminating the animal's ability to red-shift its photoreceptor spectral sensitivity and reducing its ability to see and respond to near-infrared light. Thus, the expression of a single enzyme mediates dynamic spectral tuning of the entire visual system by controlling the balance of vitamin A1 and A2 in the eye.
- Subjects :
- Infrared Rays
General Biochemistry, Genetics and Molecular Biology
Amphibian Proteins
chemistry.chemical_compound
food
Cytochrome P-450 Enzyme System
Animals
Photopigment
Vitamin A
Zebrafish
Retinal chromophore
Vitamin a1
Rana catesbeiana
biology
Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Retinal
Zebrafish Proteins
biology.organism_classification
Cell biology
Cytochrome P450 Family
Spectral sensitivity
Biochemistry
chemistry
Visual Perception
food.nutrient
General Agricultural and Biological Sciences
Vitamin A2
Transcriptome
Photoreceptor Cells, Vertebrate
Subjects
Details
- ISSN :
- 09609822
- Volume :
- 25
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Current Biology
- Accession number :
- edsair.doi.dedup.....f80215314498105872dbc84cba5e3d54
- Full Text :
- https://doi.org/10.1016/j.cub.2015.10.018