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Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction
- Source :
- Journal of Chromatography A. 1280:117-121
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Microfluidic devices have shown great potential for the production of positron emission tomography (PET) radiotracers, but most devices have focused only on the synthesis step of the procedure, typically neglecting the other important steps such as [ 18 F]fluoride pre-concentration and radiotracer purification that could equally benefit from miniaturisation. Here, we demonstrate the development of microfluidic modules for the purification of PET radiotracers, particularly 2-[ 18 F]fluoro-2-deoxy- d -glucose ([ 18 F]FDG), via the use of on-chip solid-phase extraction (SPE). In these initial tests, the SPE modules were able to yield [ 18 F]FDG with up to 90% radiochemical purity, and methods are proposed for further increasing this value.
- Subjects :
- Chromatography
medicine.diagnostic_test
010405 organic chemistry
Chemistry
Solid Phase Extraction
Organic Chemistry
Extraction (chemistry)
2 18f fluoro 2 deoxy d glucose
General Medicine
Microfluidic Analytical Techniques
01 natural sciences
Biochemistry
030218 nuclear medicine & medical imaging
0104 chemical sciences
Analytical Chemistry
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron emission tomography
Yield (chemistry)
medicine
Solid phase extraction
Radiopharmaceuticals
Subjects
Details
- ISSN :
- 00219673
- Volume :
- 1280
- Database :
- OpenAIRE
- Journal :
- Journal of Chromatography A
- Accession number :
- edsair.doi.dedup.....f80209e6e13d9ab26298655d4377f12a