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Mild traumatic brain injury impairs the coordination of intrinsic and motor-related neural dynamics
- Source :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 32, Iss, Pp 102841-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Highlights • MTBI is poorly understood and lacks objective diagnostic and prognostic tools. • Abnormal neural oscillations are found in subjects with a history of mTBI. • We identify transient bursts in MEG data using a Hidden Markov Model. • We explain a deficit in beta connectivity and power in terms of transient bursts. • Data-driven feature selection identifies symptom-relevant functional connections.<br />Mild traumatic brain injury (mTBI) poses a considerable burden on healthcare systems. Whilst most patients recover quickly, a significant number suffer from sequelae that are not accompanied by measurable structural damage. Understanding the neural underpinnings of these debilitating effects and developing a means to detect injury, would address an important unmet clinical need. It could inform interventions and help predict prognosis. Magnetoencephalography (MEG) affords excellent sensitivity in probing neural function and presents significant promise for assessing mTBI, with abnormal neural oscillations being a potential specific biomarker. However, growing evidence suggests that neural dynamics are (at least in part) driven by transient, pan-spectral bursting and in this paper, we employ this model to investigate mTBI. We applied a Hidden Markov Model to MEG data recorded during resting state and a motor task and show that previous findings of diminished intrinsic beta amplitude in individuals with mTBI are largely due to the reduced beta band spectral content of bursts, and that diminished beta connectivity results from a loss in the temporal coincidence of burst states. In a motor task, mTBI results in diminished burst amplitude, altered modulation of burst probability during movement, and a loss in connectivity in motor networks. These results suggest that, mechanistically, mTBI disrupts the structural framework underlying neural synchrony, which impairs network function. Whilst the damage may be too subtle for structural imaging to see, the functional consequences are detectable and persist after injury. Our work shows that mTBI impairs the dynamic coordination of neural network activity and proposes a potent new method for understanding mTBI.
- Subjects :
- Traumatic brain injury
Cognitive Neuroscience
Computer applications to medicine. Medical informatics
Concussion
R858-859.7
Bursting
mTBI
medicine
Beta bursts
Humans
Radiology, Nuclear Medicine and imaging
RC346-429
Brain Concussion
MEG
Resting state fMRI
Artificial neural network
medicine.diagnostic_test
business.industry
Brain
Magnetoencephalography
Regular Article
medicine.disease
Magnetic Resonance Imaging
Motor task
Neurology
Neural function
Neurology (clinical)
Neurology. Diseases of the nervous system
Networks
business
Neuroscience
mild Traumatic Brain Injury
Subjects
Details
- Language :
- English
- ISSN :
- 22131582
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- NeuroImage : Clinical
- Accession number :
- edsair.doi.dedup.....f7f4af19f43930c1d2f4b5cab5d81a12