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Methionine restriction slows down senescence in human diploid fibroblasts
- Source :
- Aging Cell
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Methionine restriction (MetR) extends lifespan in animal models including rodents. Using human diploid fibroblasts (HDF), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex IV and diminished the accumulation of reactive oxygen species. Lifespan extension was accompanied by a significant decrease in the levels of subunits of mitochondrial complex IV, but also complex I, which was due to a decreased translation rate of several mtDNA-encoded subunits. Together, these findings indicate that MetR slows down aging in human cells by modulating mitochondrial protein synthesis and respiratory chain assembly.
- Subjects :
- Senescence
Aging
Respiratory chain
Mitochondrion
Biology
medicine.disease_cause
fibroblast
chemistry.chemical_compound
medicine
Animals
Humans
cellular senescence
Fibroblast
methionine
chemistry.chemical_classification
Reactive oxygen species
Methionine
Age Factors
Translation (biology)
Original Articles
Cell Biology
Fibroblasts
Diploidy
Mitochondria
Cell biology
Disease Models, Animal
Oxidative Stress
medicine.anatomical_structure
Biochemistry
chemistry
Oxidative stress
Subjects
Details
- ISSN :
- 14749726 and 14749718
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Aging Cell
- Accession number :
- edsair.doi.dedup.....f7f237748a42c465ed4fbd235e0272c1
- Full Text :
- https://doi.org/10.1111/acel.12266