Back to Search
Start Over
Comparative effects of dextrans, gelatin and stable plasma protein solution (SPPS) on the experimental disseminated intravascular coagulation (DIC)
- Source :
- Vox sanguinis. 27(5)
- Publication Year :
- 1974
-
Abstract
- In an experimental study on the rabbit (80 animals) the haemostasis changes observed during the perfusion of dextrans of various molecular weights, gelatin and stable plasma protein solution (1.5 g/kg/h during 3 h) are compared using the normal animal and the animal with DIC induced by thrombin perfusion (100 U/kg/h during 3 h). With the normal animal, no significant disorders of haemostasis have been observed during perfusion of dextran 40 or SPPS. On the contrary, the perfusions with dextran 75 or gelatin are associated with modifications of platelet activities and of platelet and plasma plasmininhibiting activities similar to those found in thrombophilia states. Perfusion with dextran 200 produces haemostasis changes similar to those found during consumptive coagulopathies. In the animals with DIC, preventive, simultaneous or curative administration of dextrans 40, 75, 200 or gelatin significantly enhances the haemostasis disorders produced by perfusion with thrombin alone, this is opposed to SPPS which has no influence.
- Subjects :
- Blood Platelets
Male
Pathology
medicine.medical_specialty
Immunodiffusion
food.ingredient
Platelet Aggregation
Guinea Pigs
Dextran 40
Pharmacology
Gelatin
Thromboplastin
chemistry.chemical_compound
food
Thrombin
Platelet Adhesiveness
medicine
Animals
Platelet
Fibrinolysin
Stable plasma protein solution
Disseminated intravascular coagulation
Fibrin
business.industry
Immune Sera
Fibrinogen
Heparin Antagonists
Dextrans
Hematology
General Medicine
Blood Proteins
Disseminated Intravascular Coagulation
medicine.disease
Blood Cell Count
Dextran
chemistry
Rabbits
business
Perfusion
medicine.drug
Subjects
Details
- ISSN :
- 00429007
- Volume :
- 27
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Vox sanguinis
- Accession number :
- edsair.doi.dedup.....f7ebf46ad1ef2687957251d9c7956dc4