Back to Search
Start Over
KLHL3 single-nucleotide polymorphism is associated with essential hypertension in Chinese Han population
- Source :
- Medicine
- Publication Year :
- 2019
- Publisher :
- Wolters Kluwer Health, 2019.
-
Abstract
- Hypertension, including secondary and essential hypertension (EH) variants, is a multifactorial disease, affecting more than one billion people worldwide. Secondary hypertension results from mutations in the putative gene KLHL3 (Kelch-like protein 3); however, it has not been reported whether the KLHL3 gene polymorphisms are associated with EH. Here, we investigated the association between KLHL3 (rs2301708 and rs7444370) polymorphisms and EH in the Chinese Han population. This case–control study included 522 subjects—260 patients with EH and 262 normotensive controls matched for age, gender, body mass index (BMI), hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), and levels of Na+, K+, and Cl−. The distribution of functional rs2301708 and rs7444370 polymorphisms within the KLHL3 gene was assessed through polymerase chain reaction (PCR) and restriction-fragment length polymorphism (RFLP). There was no significant difference in allelic and genotypic frequencies of KLHL3 rs2301708 between the EH and normotensive groups; however, the rs7444370 T allele and CT genotype in females was significantly associated with a protective effect against EH (P = .001, P = .002; P = .019, P = .052), and the haplotype CT of rs2301708 and rs7444370 among females in the EH group was less than in the normotensive group (P = .000; P = .007). The KLHL3 rs7444370 variant could be a protective factor in the pathogenesis of females’ EH.
- Subjects :
- Male
medicine.medical_specialty
haplotype
China
Genotype
Secondary hypertension
Observational Study
Single-nucleotide polymorphism
Essential hypertension
Gastroenterology
Polymorphism, Single Nucleotide
03 medical and health sciences
0302 clinical medicine
Asian People
Gene Frequency
Internal medicine
medicine
Humans
030212 general & internal medicine
Allele
Genetic Association Studies
Adaptor Proteins, Signal Transducing
Aged
Aged, 80 and over
business.industry
Haplotype
Microfilament Proteins
essential hypertension
General Medicine
Middle Aged
medicine.disease
Chinese Han population
030220 oncology & carcinogenesis
Case-Control Studies
KLHL3
Female
Restriction fragment length polymorphism
business
polymorphisms
Carrier Proteins
Body mass index
Polymorphism, Restriction Fragment Length
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 98
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....f7cd54f5472a5ac008e3ff943c50dbef