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LhARA: The Laser-hybrid Accelerator for Radiobiological Applications
LhARA: The Laser-hybrid Accelerator for Radiobiological Applications
- Source :
- BASE-Bielefeld Academic Search Engine, Frontiers in Physics, Vol 8 (2020), Aymar, G, Becker, T, Boogert, S, Borghesi, M, Bingham, R, Brenner, C, Burrows, P N, Ettlinger, O C, Dascalu, T, Gibson, S, Greenshaw, T, Gruber, S, Gujral, D, Hardiman, C, Hughes, J, Jones, W G, Kirkby, K, Kurup, A, Lagrange, J B, Long, K, Luk, W, Matheson, J, McKenna, P, McLauchlan, R, Najmudin, Z, Lau, H T, Parsons, J L, Pasternak, J, Pozimski, J, Prise, K, Puchalska, M, Ratoff, P, Schettino, G, Shields, W, Smith, S, Thomason, J, Towe, S, Weightman, P, Whyte, C & Xiao, R 2020, ' LhARA: The Laser-hybrid Accelerator for Radiobiological Applications ', Frontiers in Physics, vol. 8, 567738 . https://doi.org/10.3389/fphy.2020.567738, Frontiers in Physics, Medical Physics and Imaging, Aymar, G, Becker, T, Boogert, S, Borghesi, M, Bingham, R, Brenner, C, Burrows, P N, Ettlinger, O C, Dascalu, T, Gibson, S, Greenshaw, T, Gruber, S, Gujral, D, Hardiman, C, Hughes, J, Jones, W G, Kirkby, K, Kurup, A, Lagrange, J-B, Long, K, Luk, W, Matheson, J, McKenna, P, McLauchlan, R, Najmudin, Z, Lau, H T, Parsons, J L, Pasternak, J, Pozimski, J, Prise, K, Puchalska, M, Ratoff, P, Schettino, G, Shields, W, Smith, S, Thomason, J, Towe, S, Weightman, P, Whyte, C & Xiao, R 2020, ' LhARA : The Laser-hybrid Accelerator for Radiobiological Applications ', Frontiers in Physics, vol. 8, 567738, pp. 1-21 . https://doi.org/10.3389/fphy.2020.567738, FRONTIERS IN PHYSICS
- Publication Year :
- 2020
- Publisher :
- Frontiers Media SA, 2020.
-
Abstract
- The “Laser-hybrid Accelerator for Radiobiological Applications,” LhARA, is conceived as a novel, flexible facility dedicated to the study of radiobiology. The technologies demonstrated in LhARA, which have wide application, will be developed to allow particle-beam therapy to be delivered in a new regimen, combining a variety of ion species in a single treatment fraction and exploiting ultra-high dose rates. LhARA will be a hybrid accelerator system in which laser interactions drive the creation of a large flux of protons or light ions that are captured using a plasma (Gabor) lens and formed into a beam. The laser-driven source allows protons and ions to be captured at energies significantly above those that pertain in conventional facilities, thus evading the current space-charge limit on the instantaneous dose rate that can be delivered. The laser-hybrid approach, therefore, will allow the radiobiology that determines the response of tissue to ionizing radiation to be studied with protons and light ions using a wide variety of time structures, spectral distributions, and spatial configurations at instantaneous dose rates up to and significantly beyond the ultra-high dose-rate “FLASH” regime. It is proposed that LhARA be developed in two stages. In the first stage, a programme of in vitro radiobiology will be served with proton beams with energies between 10 and 15 MeV. In stage two, the beam will be accelerated using a fixed-field alternating-gradient accelerator (FFA). This will allow experiments to be carried out in vitro and in vivo with proton beam energies of up to 127 MeV. In addition, ion beams with energies up to 33.4 MeV per nucleon will be available for in vitro and in vivo experiments. This paper presents the conceptual design for LhARA and the R&D programme by which the LhARA consortium seeks to establish the facility.
- Subjects :
- laser-driven acceleration
Proton
fixed-field alternating-gradient acceleration
Quantitative Biology::Tissues and Organs
Materials Science (miscellaneous)
Physics::Medical Physics
Biophysics
General Physics and Astronomy
Physics and Astronomy(all)
novel acceleration
01 natural sciences
law.invention
Ion
Ionizing radiation
Nuclear physics
law
0103 physical sciences
Physical and Theoretical Chemistry
010306 general physics
QC
Mathematical Physics
Physics
proton beam therapy (PBT)
Plasma
plasma lens
Laser
lcsh:QC1-999
Lens (optics)
radiobiology
Physics::Accelerator Physics
ion beam therapy
Nucleon
lcsh:Physics
Beam (structure)
Subjects
Details
- ISSN :
- 2296424X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physics
- Accession number :
- edsair.doi.dedup.....f7b9c88c839686b7f6b09b8cea938958
- Full Text :
- https://doi.org/10.3389/fphy.2020.567738