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LhARA: The Laser-hybrid Accelerator for Radiobiological Applications

LhARA: The Laser-hybrid Accelerator for Radiobiological Applications

Authors :
Karen J. Kirkby
Zulfikar Najmudin
Monika Puchalska
William Shields
Ruth Mclauchlan
Titus-Stefan Dascalu
Galen Aymar
Tobias Becker
Stephen Gibson
Jason L. Parsons
Kenneth Long
Giuseppe Schettino
Paul McKenna
Wendy Jones
Marco Borghesi
Kevin M. Prise
Dorothy M. Gujral
T. Greenshaw
Colin G. Whyte
Ceri Brenner
Rachel Xiao
Philip Burrows
Sylvia Gruber
Stephen Towe
Jaroslaw Pasternak
J. Thomason
Peter Weightman
Stewart Boogert
J. Matheson
S.L. Smith
Robert Bingham
O. C. Ettlinger
Juergen Pozimski
H. T. Lau
Wayne Luk
Jean-Baptiste Lagrange
A. Kurup
Claire Hardiman
P. N. Ratoff
Jonathan R Hughes
Science and Technology Facilities Council (STFC)
Engineering & Physical Science Research Council (E
Science and Technology Facilities Council [2006-2012]
The John Adams Institute for Accelerator Science Capital Equipment 2018
Source :
BASE-Bielefeld Academic Search Engine, Frontiers in Physics, Vol 8 (2020), Aymar, G, Becker, T, Boogert, S, Borghesi, M, Bingham, R, Brenner, C, Burrows, P N, Ettlinger, O C, Dascalu, T, Gibson, S, Greenshaw, T, Gruber, S, Gujral, D, Hardiman, C, Hughes, J, Jones, W G, Kirkby, K, Kurup, A, Lagrange, J B, Long, K, Luk, W, Matheson, J, McKenna, P, McLauchlan, R, Najmudin, Z, Lau, H T, Parsons, J L, Pasternak, J, Pozimski, J, Prise, K, Puchalska, M, Ratoff, P, Schettino, G, Shields, W, Smith, S, Thomason, J, Towe, S, Weightman, P, Whyte, C & Xiao, R 2020, ' LhARA: The Laser-hybrid Accelerator for Radiobiological Applications ', Frontiers in Physics, vol. 8, 567738 . https://doi.org/10.3389/fphy.2020.567738, Frontiers in Physics, Medical Physics and Imaging, Aymar, G, Becker, T, Boogert, S, Borghesi, M, Bingham, R, Brenner, C, Burrows, P N, Ettlinger, O C, Dascalu, T, Gibson, S, Greenshaw, T, Gruber, S, Gujral, D, Hardiman, C, Hughes, J, Jones, W G, Kirkby, K, Kurup, A, Lagrange, J-B, Long, K, Luk, W, Matheson, J, McKenna, P, McLauchlan, R, Najmudin, Z, Lau, H T, Parsons, J L, Pasternak, J, Pozimski, J, Prise, K, Puchalska, M, Ratoff, P, Schettino, G, Shields, W, Smith, S, Thomason, J, Towe, S, Weightman, P, Whyte, C & Xiao, R 2020, ' LhARA : The Laser-hybrid Accelerator for Radiobiological Applications ', Frontiers in Physics, vol. 8, 567738, pp. 1-21 . https://doi.org/10.3389/fphy.2020.567738, FRONTIERS IN PHYSICS
Publication Year :
2020
Publisher :
Frontiers Media SA, 2020.

Abstract

The “Laser-hybrid Accelerator for Radiobiological Applications,” LhARA, is conceived as a novel, flexible facility dedicated to the study of radiobiology. The technologies demonstrated in LhARA, which have wide application, will be developed to allow particle-beam therapy to be delivered in a new regimen, combining a variety of ion species in a single treatment fraction and exploiting ultra-high dose rates. LhARA will be a hybrid accelerator system in which laser interactions drive the creation of a large flux of protons or light ions that are captured using a plasma (Gabor) lens and formed into a beam. The laser-driven source allows protons and ions to be captured at energies significantly above those that pertain in conventional facilities, thus evading the current space-charge limit on the instantaneous dose rate that can be delivered. The laser-hybrid approach, therefore, will allow the radiobiology that determines the response of tissue to ionizing radiation to be studied with protons and light ions using a wide variety of time structures, spectral distributions, and spatial configurations at instantaneous dose rates up to and significantly beyond the ultra-high dose-rate “FLASH” regime. It is proposed that LhARA be developed in two stages. In the first stage, a programme of in vitro radiobiology will be served with proton beams with energies between 10 and 15 MeV. In stage two, the beam will be accelerated using a fixed-field alternating-gradient accelerator (FFA). This will allow experiments to be carried out in vitro and in vivo with proton beam energies of up to 127 MeV. In addition, ion beams with energies up to 33.4 MeV per nucleon will be available for in vitro and in vivo experiments. This paper presents the conceptual design for LhARA and the R&D programme by which the LhARA consortium seeks to establish the facility.

Details

ISSN :
2296424X
Volume :
8
Database :
OpenAIRE
Journal :
Frontiers in Physics
Accession number :
edsair.doi.dedup.....f7b9c88c839686b7f6b09b8cea938958
Full Text :
https://doi.org/10.3389/fphy.2020.567738