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Oral iron-based interventions for prevention of critical outcomes in pregnancy and postnatal care: An overview and update of systematic reviews
- Publication Year :
- 2019
-
Abstract
- Objective The aim of this work was to summarize and update the evidence concerning oral iron-based interventions compared to placebo or no iron-based interventions to prevent critical outcomes in pregnancy or treat critical outcomes in the postpartum phase. Method Published systematic reviews (Feb 2018) and primary studies (from 2015 to March 2018) retrieved from MEDLINE, EMBASE, and the Cochrane Library were examined. The AMSTAR (Assessing the Methodological Quality of Systematic Reviews) tool was used to assess the quality of reviews. GRADE was used to rate the quality of the evidence for critical outcomes. Results Antenatal care: Compared to placebo/no treatment, iron-based therapies reduced maternal anemia at term by 59% (seven trials at low risk of bias, RR 0.41, 95% CI 0.23-0.73; I2 = 86%; moderate-quality evidence) and maternal iron deficiency anemia by 67% (RR 0.33, 95% CI 0.16-0.69; I2 = 49%). There was no evidence of difference between iron-based therapies vs control in terms of side effects (RR 1.42, 95% CI 0.91-2.21), preterm delivery (13 studies: RR 0.93, 95% CI 0.84-1.03; low-quality evidence), low birthweight (RR 0.94, 95% CI 0.79-1.13; low-quality evidence) and infant mortality (RR 0.93, 0.72-1.20; low-quality evidence). Postnatal care There was insufficient evidence to determine whether iron-based therapies can reduce postpartum anemia. Conclusion Iron supplementation is effective in preventing maternal anemia at term but not low birthweight, preterm delivery or infant mortality.
- Subjects :
- Postnatal Care
Oral
Pediatrics
medicine.medical_specialty
maternal anemia
Anemia
Iron
systematic reviews
Administration, Oral
Cochrane Library
Placebo
03 medical and health sciences
0302 clinical medicine
Pregnancy
Infant Mortality
medicine
Humans
030212 general & internal medicine
Randomized Controlled Trials as Topic
iron therapy
Evidence-Based Medicine
business.industry
Health Policy
Low Birth Weight
Infant
Prenatal Care
General Medicine
Infant, Low Birth Weight
medicine.disease
Infant mortality
Systematic review
Iron-deficiency anemia
Administration
Premature Birth
Female
business
030217 neurology & neurosurgery
pregnancy
Systematic Reviews as Topic
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f7a68717f6cdc28b3ffb67d4f1a92401