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Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity
- Source :
- The British journal of psychiatry : the journal of mental science. 216(5)
- Publication Year :
- 2019
-
Abstract
- BackgroundSchizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated.AimsTo investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functional connectivity, which are disrupted in schizophrenia.MethodGenomic and neuroimaging data from a large sample of Han Chinese patients with schizophrenia (N = 509) and healthy controls (N = 502) were included in this study. We examined grey matter volume and functional connectivity via structural and functional magnetic resonance imaging, respectively. Using the data from a recent meta-analysis of a genome-wide association study that comprised a large number of Chinese people, we calculated a polygenic risk score (PGRS) for each participant.ResultsThe imaging genetic analysis revealed that the individual PGRS showed a significantly negative correlation with the hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity, both of which were lower in the people with schizophrenia than in the controls. We also found that the observed neuroimaging measures showed weak but similar changes in unaffected first-degree relatives of patients with schizophrenia.ConclusionsThese findings suggested that genetically influenced brain grey matter volume and functional connectivity may provide important clues for understanding the pathological mechanisms of schizophrenia and for the early diagnosis of schizophrenia.
- Subjects :
- Adult
Male
Multifactorial Inheritance
Adolescent
Hippocampus
Prefrontal Cortex
Biology
Grey matter
Hippocampal formation
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Humans
Gray Matter
Prefrontal cortex
030304 developmental biology
0303 health sciences
Functional connectivity
Middle Aged
medicine.disease
Chinese academy of sciences
Magnetic Resonance Imaging
Psychiatry and Mental health
medicine.anatomical_structure
Schizophrenia
Female
National laboratory
Neuroscience
030217 neurology & neurosurgery
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14721465 and 00071250
- Volume :
- 216
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The British journal of psychiatry : the journal of mental science
- Accession number :
- edsair.doi.dedup.....f7929abc47d9fa6f60beb3ad5963862d