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Angiotensin II-forming pathways in normal and failing human hearts
- Source :
- Circulation Research. 66:883-890
- Publication Year :
- 1990
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1990.
-
Abstract
- Reduced preload and afterload to the heart are important effects of angiotensin converting enzyme (ACE) inhibitors in the treatment of congestive heart failure. However, since angiotensin II (Ang II) directly increases the strength of myocardial contraction, suppression of Ang II formation by ACE inhibitors could potentially reduce the beneficial effects of Ang II on the failing heart. To study how ACE inhibition suppresses cardiac Ang II formation in man, we characterized ACE-dependent and ACE-independent Ang II-forming pathways in eight normal and 24 failing human hearts obtained at cardiac transplantation. Ang II-forming activity in left ventricular (LV) membrane preparations was assessed by measuring the conversion of [125I]angiotensin I (Ang I) to [125I]Ang II. LV [125I]Ang II-forming activity in normal hearts (35.5 +/- 2.7 fmol/min/mg, n = 8) was not different from that in hearts from patients with ischemic cardiomyopathy (25.5 +/- 2.9 fmol/min/mg, n = 9) and was 48% lower (p less than 0.001) in hearts from patients with idiopathic cardiomyopathy (18.5 +/- 1.9 fmol/min/mg, n = 15).(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Adult
Male
medicine.medical_specialty
Cardiac output
Captopril
Adolescent
Physiology
Heart Ventricles
Cardiac Output, Low
Peptidyl-Dipeptidase A
Afterload
Reference Values
Internal medicine
Renin–angiotensin system
medicine
Humans
Ischemic cardiomyopathy
biology
Chemistry
Angiotensin II
Myocardium
Heart
Angiotensin-converting enzyme
Middle Aged
medicine.disease
Transplantation
Endocrinology
Heart failure
cardiovascular system
biology.protein
Female
Soybeans
Angiotensin I
Trypsin Inhibitors
Cardiology and Cardiovascular Medicine
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15244571 and 00097330
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Circulation Research
- Accession number :
- edsair.doi.dedup.....f7857f954f5b49a2ae363b77b1d3dd0e