Back to Search Start Over

Non-Cytopathic Bovine Viral Diarrhea Virus Infection Inhibits Differentiation of Bovine Neural Stem/progenitor Cells into Astrocytes in Vitro

Authors :
Yoshihiro Sakoda
Masateru Koiwa
Kazuya Matsuda
Ken-ichiro Kameyama
Shintaro Kobayashi
Hiroyuki Taniyama
Michiko Sato
Source :
Journal of Veterinary Medical Science. 72(7):903-907
Publication Year :
2010
Publisher :
日本獣医学会, 2010.

Abstract

Bovine viral diarrhea virus (BVDV) causes fetal brain malformations in ruminants when the fetuses are infected transplacentally in mid-pregnancy. In both cytopathic and non-cytopatic virus infections, viral lytic infection in actively replicating cells and interruption of vascular integrity have been suggested as the pathogenesis, but functional disturbance of infected neural developing cells has been unclear. In this study, we examined the effect of infection with non-cytopathic BVDV2 on the differentiation of neural stem/precursor cells isolated from the bovine fetus. In the process of differentiation to three types of neural cells, neurons, astrocytes and oligo-dendrocytes, virus infection significantly and selectively inhibited the differentiation of neural stem/precursor cells into the astrocytic lineage. This inhibition is possibly important for the pathogenesis of congenital brain malformations associated with non-cytopathic BVDV infection.

Details

Language :
English
ISSN :
09167250
Volume :
72
Issue :
7
Database :
OpenAIRE
Journal :
Journal of Veterinary Medical Science
Accession number :
edsair.doi.dedup.....f78431b416742763fa6dd8db406dd677