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Non-Cytopathic Bovine Viral Diarrhea Virus Infection Inhibits Differentiation of Bovine Neural Stem/progenitor Cells into Astrocytes in Vitro
- Source :
- Journal of Veterinary Medical Science. 72(7):903-907
- Publication Year :
- 2010
- Publisher :
- 日本獣医学会, 2010.
-
Abstract
- Bovine viral diarrhea virus (BVDV) causes fetal brain malformations in ruminants when the fetuses are infected transplacentally in mid-pregnancy. In both cytopathic and non-cytopatic virus infections, viral lytic infection in actively replicating cells and interruption of vascular integrity have been suggested as the pathogenesis, but functional disturbance of infected neural developing cells has been unclear. In this study, we examined the effect of infection with non-cytopathic BVDV2 on the differentiation of neural stem/precursor cells isolated from the bovine fetus. In the process of differentiation to three types of neural cells, neurons, astrocytes and oligo-dendrocytes, virus infection significantly and selectively inhibited the differentiation of neural stem/precursor cells into the astrocytic lineage. This inhibition is possibly important for the pathogenesis of congenital brain malformations associated with non-cytopathic BVDV infection.
- Subjects :
- viruses
Cell Culture Techniques
Biology
Virus
Pathogenesis
Precursor cell
medicine
Animals
Progenitor cell
Neurons
General Veterinary
Diarrhea Virus 1, Bovine Viral
Stem Cells
Brain
Cell Differentiation
Fibroblasts
Virology
In vitro
Neural stem cell
Oligodendroglia
medicine.anatomical_structure
Lytic cycle
Astrocytes
Cattle
Cell Division
Astrocyte
Subjects
Details
- Language :
- English
- ISSN :
- 09167250
- Volume :
- 72
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Medical Science
- Accession number :
- edsair.doi.dedup.....f78431b416742763fa6dd8db406dd677