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Measurement of Equilibrium Angiotensin II in the Diagnosis of Primary Aldosteronism
- Source :
- Clinical Chemistry. 66:483-492
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Background Many medications (including most antihypertensives) and physiological factors affect the aldosterone/renin ratio (ARR) when screening for primary aldosteronism (PA). We sought to validate a novel equilibrium angiotensin II (eqAngII) assay and compare correlations between the aldosterone/angiotensin II ratio (AA2R) and the current ARR under conditions affecting the renin-angiotensin system. Methods Among 78 patients recruited, PA was excluded in 22 and confirmed in 56 by fludrocortisone suppression testing (FST). Peripheral levels of eqAngII, plasma renin activity (PRA) and direct renin concentration (DRC) were measured. Results EqAngII showed good consistency with DRC and PRA independent of PA diagnosis, posture, and fludrocortisone administration. EqAngII showed close (P Conclusions Dynamic changes of eqAngII and the AA2R show good consistency and close correlations with renin and the ARR. The eqAngII assay shows better sensitivity than DRC and PRA assays, especially at low concentrations. Whether the AA2R can reduce the impact of some factors that influence the diagnostic power of the ARR warrants further study.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Fludrocortisone
Clinical Biochemistry
Radioimmunoassay
Urology
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Plasma renin activity
Low renin levels
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Primary aldosteronism
Tandem Mass Spectrometry
Hyperaldosteronism
Renin
Renin–angiotensin system
medicine
Humans
Aldosterone
Chromatography, High Pressure Liquid
Volume concentration
Aged
Immunoassay
business.industry
Angiotensin II
Biochemistry (medical)
Middle Aged
medicine.disease
chemistry
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15308561 and 00099147
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Clinical Chemistry
- Accession number :
- edsair.doi.dedup.....f774bb3b8a63670540f75a813e160ef1