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The Complete Genome Sequence of the Staphylococcus Bacteriophage Metroid
- Source :
- G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 2975-2979 (2020)
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Phages infecting bacteria of the genus Staphylococcus play an important role in their host’s ecology and evolution. On one hand, horizontal gene transfer from phage can encourage the rapid adaptation of pathogenic Staphylococcus enabling them to escape host immunity or access novel environments. On the other hand, lytic phages are promising agents for the treatment of bacterial infections, especially those resistant to antibiotics. As part of an ongoing effort to gain novel insights into bacteriophage diversity, we characterized the complete genome of the Staphylococcus bacteriophage Metroid, a cluster C phage with a genome size of 151kb, encompassing 254 predicted protein-coding genes as well as 4 tRNAs. A comparative genomic analysis highlights strong similarities – including a conservation of the lysis cassette – with other Staphylococcus cluster C1 bacteriophages, several of which were previously characterized for therapeutic applications.
- Subjects :
- Myoviridae
de novo assembly
QH426-470
medicine.disease_cause
Genome
Bacteriophage
03 medical and health sciences
bacteriophage
medicine
Genetics
Molecular Biology
Genome size
Gene
Genetics (clinical)
030304 developmental biology
Whole genome sequencing
0303 health sciences
biology
030306 microbiology
biology.organism_classification
gene annotation
Lytic cycle
Horizontal gene transfer
myoviridae
Staphylococcus
Subjects
Details
- ISSN :
- 21601836
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- G3 Genes|Genomes|Genetics
- Accession number :
- edsair.doi.dedup.....f770c291f4567fb55c92dd3ce15a2e0e