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Intestinal permeability and Ménière's disease
- Source :
- American journal of otolaryngology. 39(2)
- Publication Year :
- 2017
-
Abstract
- Purpose: Ménière disease (MD) is a multifactorial chronic disabling condition characterized by episodic vertigo, ear fullness, and hearing loss. MD patients often complain of aspecific gastrointestinal symptoms associated with autonomic dysregulation, frequently outweighed by the otological manifestations. Dietary modifications have been reported to improve the typical MD symptoms in some cases. Our purpose was to test the urinary levels of lactulose and mannitol (double sugar test) and the fecal calprotectin, both markers of altered intestinal permeability, in subjects with definite MD in an active and inactive stage. Materials and methods: Twenty-six with definite unilateral MD were studied: 14 patients were symptomatic for at least 3 months with moderate to severe vertigo spells and a functional level ≥ 4; 12 patients had been asymptomatic (no vertigo spells) for at least 3 months and had a functional level = 1 at the time of testing. Twenty healthy volunteers were recruited as “control group”. Results: Lactulose and mannitol absorption was significantly increased in the symptomatic M patients compared to the asymptomatic group (p < 0.02 and p < 0.004, respectively) and to the controls. FC were also higher than normal only in the symptomatic group. (p < 0.01). Conclusions: An altered intestinal permeability, according to the two assays, was found only in symptomatic MD patients. The rationale for a possible relationship between MD and intestinal permeability is forwarded. The double-sugar test and FC quantification might be implemented in the MD diagnostic workup
- Subjects :
- Male
medicine.medical_specialty
mass spectrometry, metabolomics, neurodegenerative diseases
Hearing loss
Gastroenterology
Asymptomatic
03 medical and health sciences
Lactulose
0302 clinical medicine
Internal medicine
Vertigo
medicine
Humans
Mannitol
Stage (cooking)
Intestinal Mucosa
030223 otorhinolaryngology
Meniere Disease
Intestinal permeability
biology
business.industry
Middle Aged
biology.organism_classification
medicine.disease
Magnetic Resonance Imaging
Glucose
Otorhinolaryngology
Intestinal Absorption
030211 gastroenterology & hepatology
Female
medicine.symptom
Calprotectin
business
medicine.drug
Meniere's disease
Subjects
Details
- ISSN :
- 1532818X
- Volume :
- 39
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- American journal of otolaryngology
- Accession number :
- edsair.doi.dedup.....f7562f021f80267a7b7b010fd15cee9a