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Expression of ORL1 mRNA in some brain nuclei in neuropathic pain rats
- Source :
- Brain research. 1043(1-2)
- Publication Year :
- 2004
-
Abstract
- The present study was designed to investigate changes of opioid receptor like 1 receptor (ORL(1), NOP) mRNA expression in some pain-related brain nuclei of neuropathic pain rats using in situ hybridization technique. Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of ORL(1), plays an important role in neuropathic pain through its receptor. There are ORL(1) mRNA expression in the nucleus of raphe magnus (NRM), ventrolateral periaqueductal gray (vlPAG) and dorsal raphe nucleus (DRN) of rat mesencephalon. In the sciatic nerve chronic constriction injury (CCI)-induced neuropathic pain model, a significant increase of ORL(1) mRNA expression was observed in these three regions on the 7th day after operation, and the changes lasted for 2 weeks. The result indicated that ORL(1) synthesis was increased in NRM, vlPAG and DRN of neuropathic pain rats, suggesting that ORL(1) was involved in nociceptive transmission of neuropathic pain.
- Subjects :
- Male
medicine.medical_specialty
NOP
Central nervous system
Gene Expression
Nociceptin Receptor
Rats, Sprague-Dawley
Sciatica
Dorsal raphe nucleus
Internal medicine
medicine
Animals
Periaqueductal Gray
RNA, Messenger
Molecular Biology
In Situ Hybridization
Nucleus raphe magnus
business.industry
General Neuroscience
Rats
Nociceptin receptor
Endocrinology
medicine.anatomical_structure
Nociception
Neuropathic pain
Receptors, Opioid
Raphe Nuclei
Neurology (clinical)
Sciatic nerve
business
Neuroscience
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 1043
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Brain research
- Accession number :
- edsair.doi.dedup.....f74a2946f03367e2be077f742b6432ff