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Co-exposure to polycyclic aromatic hydrocarbons and metals, four common polymorphisms in microRNA genes, and their gene-environment interactions: Influences on oxidative damage levels in Chinese coke oven workers
- Source :
- Environment International, Vol 132, Iss, Pp-(2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Background: Human are often simultaneously exposed to polycyclic aromatic hydrocarbons (PAHs) and metals, yet relatively little is known regarding their co-exposure effects on oxidative damage. Genetic factors and the gene-environment interactions can also determine the severity of oxidative damage. Four polymorphisms in microRNA (miRNA) genes (rs11614913, rs2292832, rs2910164, and rs3746444) have been well-studied to be associated with oxidative damage-related diseases. Objective: To investigate the influences of PAH-metal co-exposure, four polymorphisms, and their interactions on oxidative damage levels. Methods: We conducted a cross-sectional study in 1385 coke oven workers. We quantified exposure levels of PAHs and metals by urinary monohydroxy-PAHs, plasma benzo[a]pyrene-7,8-diol-9,10-epoxide-albumin adducts, and urinary metals, respectively, and measured oxidative damage levels by 8-iso-prostaglandin-F2α and 8-hydroxydeoxyguanosine. We also genotyped four polymorphisms. Results: In multiple-pollutant models, 8-iso-prostaglandin-F2α and 8-hydroxydeoxyguanosine were associated with multiple PAH exposure biomarkers, as well as with multiple metals (ptrend 7.75%, false discovery rate-adjusted pinteraction ≤ 2.25 × 10−5). Significantly higher 8-hydroxydeoxyguanosine was observed in carriers of rs11614913 CC variant homozygote than TC carriers (p = 0.037). Associations of the number of rs11614913 C allele with increased 8-iso-prostaglandin-F2α and 8-hydroxydeoxyguanosine were significant (βstd > 0, ptrend
- Subjects :
- Adult
Male
medicine.medical_specialty
010504 meteorology & atmospheric sciences
Oxidative phosphorylation
010501 environmental sciences
Dinoprost
01 natural sciences
Arsenic
chemistry.chemical_compound
Asian People
Occupational Exposure
Internal medicine
Genotype
microRNA
Blood plasma
medicine
Humans
Polycyclic Aromatic Hydrocarbons
Allele
Coke
Gene
lcsh:Environmental sciences
0105 earth and related environmental sciences
General Environmental Science
lcsh:GE1-350
Polymorphism, Genetic
Chemistry
Middle Aged
Phenanthrene
MicroRNAs
Oxidative Stress
Endocrinology
8-Hydroxy-2'-Deoxyguanosine
Metals
Environmental Pollutants
Female
Gene-Environment Interaction
Polycyclic Hydrocarbons
Biomarkers
Biological Monitoring
Subjects
Details
- Language :
- English
- ISSN :
- 01604120
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Environment International
- Accession number :
- edsair.doi.dedup.....f7441a5a0a3ff253ca5d6ddf51c15eee