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Tuning DNA Binding Kinetics in an Optical Trap by Plasmonic Nanoparticle Heating
- Source :
- Nano Letters
- Publication Year :
- 2013
- Publisher :
- American Chemical Society (ACS), 2013.
-
Abstract
- We report on the tuning of specific binding of DNA attached to gold nanoparticles at the individual particle pair (dimer) level in an optical trap by means of plasmonic heating. DNA hybridization events are detected optically by the change in the plasmon resonance frequency due to plasmonic coupling of the nanoparticles. We find that at larger trapping powers (i.e., larger temperatures and stiffer traps) the hybridization rates decrease by more than an order of magnitude. This result is explained by higher temperatures preventing the formation of dimers with lower binding energies. Our results demonstrate that plasmonic heating can be used to fine tune the kinetics of biomolecular binding events.
- Subjects :
- Materials science
Light
Binding energy
Kinetics
Analytical chemistry
Metal Nanoparticles
Physics::Optics
Nanoparticle
Bioengineering
02 engineering and technology
010402 general chemistry
01 natural sciences
Heating
Coated Materials, Biocompatible
Materials Testing
Physics::Atomic and Molecular Clusters
General Materials Science
Surface plasmon resonance
Plasmon
Binding Sites
Mechanical Engineering
technology, industry, and agriculture
DNA
General Chemistry
Surface Plasmon Resonance
021001 nanoscience & nanotechnology
Condensed Matter Physics
0104 chemical sciences
Energy Transfer
Optical tweezers
Colloidal gold
Chemical physics
Gold
0210 nano-technology
Order of magnitude
Subjects
Details
- ISSN :
- 15306992 and 15306984
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nano Letters
- Accession number :
- edsair.doi.dedup.....f7440b17ecbebc1748ed9cf242f273ee