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Association of Genomic Instability with HbA1c levels and Medication in Diabetic Patients
- Source :
- Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group, 2017.
-
Abstract
- Diabetes Mellitus type 2 (DM2) is associated with increased cancer risk. Instability of the genetic material plays a key role in the aetiology of human cancer. This study aimed to analyse genomic instability with the micronucleus cytome assay in exfoliated buccal cells depending on glycated haemoglobin (HbA1c) levels and medication in 146 female DM2 patients. The occurrence of micronuclei was significantly increased in DM2 patients compared to healthy controls. Furthermore, it was doubled in DM2 patients with HbA1c > 7.5% compared to subjects with HbA1c ≤ 7.5%. Positive correlations were found between micronuclei frequencies and HbA1c as well as fasting plasma glucose. Patients under insulin treatment showed a two-fold increase in micronuclei frequencies compared to subjects under first-line medication (no drugs or monotherapy with non-insulin medication). However, after separation of HbA1c (cut-off 7.5%) only patients with severe DM2 characterised by high HbA1c and insulin treatment showed higher micronuclei frequencies but not patients with insulin treatment and low HbA1c. We demonstrated that the severity of DM2 accompanied by elevated micronuclei frequencies predict a possible enhanced cancer risk among female DM2 patients. Therapy, therefore, should focus on a strict HbA1c control and personalised medical treatments.
- Subjects :
- 0301 basic medicine
Genome instability
musculoskeletal diseases
Adult
medicine.medical_specialty
endocrine system diseases
medicine.medical_treatment
Buccal swab
Gastroenterology
Article
Genomic Instability
Cancer prevention
03 medical and health sciences
Hba1c level
Diabetes mellitus
Internal medicine
medicine
Humans
Hypoglycemic Agents
Micronuclei, Chromosome-Defective
Aged
Aged, 80 and over
Glycated Hemoglobin
Multidisciplinary
business.industry
Insulin
Mouth Mucosa
Type 2 diabetes
Middle Aged
medicine.disease
030104 developmental biology
Diabetes Mellitus, Type 2
Risk factors
Case-Control Studies
Micronucleus test
Etiology
Female
Micronucleus
business
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....f74213c44915103f525cf5ae11eec4f3
- Full Text :
- https://doi.org/10.1038/srep41985