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Effect of Therapeutic Immunization With Recombinant gp160 HIV-1 Vaccine on HIV-1 Proviral DNA and Plasma RNA
- Source :
- Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 15:269-274
- Publication Year :
- 1997
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1997.
-
Abstract
- Therapeutic vaccination has been proposed as a strategy to augment immune mechanisms to control viral replication and slow clinical progression of HIV infection to disease. Following recombinant gp160 (r-gp160) immunization in three clinical trials, plasma HIV-1 RNA and cellular proviral DNA were assessed by quantitative polymerase chain reaction (PCR) in 76 HIV-seropositive subjects with CD4+ T cell counts > or = 300/mm3. Immunization increased HIV-specific cellular immune responses (e.g., cytotoxic T lymphocyte [CTL] activities, lymphocyte proliferative responses); however, there were no significant effects of immunization or cellular immune responses on measures of plasma RNA or cellular DNA viral load.
- Subjects :
- Adult
Male
Cellular immunity
Sialoglycoproteins
animal diseases
T cell
Immunology
chemical and pharmacologic phenomena
Biology
Virus
Immune system
Proviruses
Virology
Immunopathology
medicine
Humans
Immunology and Allergy
AIDS Vaccines
Acquired Immunodeficiency Syndrome
Immunity, Cellular
Vaccines, Synthetic
virus diseases
Middle Aged
biochemical phenomena, metabolism, and nutrition
CD4 Lymphocyte Count
Real-time polymerase chain reaction
medicine.anatomical_structure
Immunization
DNA, Viral
HIV-1
RNA, Viral
bacteria
Female
Viral load
Subjects
Details
- ISSN :
- 10779450
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
- Accession number :
- edsair.doi.dedup.....f7376f20bf93d2110f509f17c1e80827