Auditory deviance detection in the human insula: An intracranial EEG study

The human insula is known to be involved in auditory processing, but knowledge about its precise functional role and the underlying electrophysiology is limited. To assess its role in automatic auditory deviance detection we analyzed the EEG high frequency activity (HFA; 75–145 Hz) and ERPs from 90 intracranial insular channels across 16 patients undergoing pre-surgical intracranial monitoring for epilepsy treatment. Subjects passively listened to a stream of standard and deviant tones differing in four physical dimensions: intensity, frequency, location or time. HFA responses to auditory stimuli were found in the short and long gyri, and the anterior, superior, and inferior segments of the circular sulcus of the insular cortex. Only a subset of channels in the inferior segment of the circular sulcus of the insula showed HFA deviance detection responses, i.e., a greater and longer latency response to specific deviants relative to standards. Auditory deviancy processing was also later in the insula when compared with the superior temporal cortex. ERP results were more widespread and supported the HFA insular findings. These results provide evidence that the human insula is engaged during auditory deviance detection. Fil: Blenkmann, Alejandro Omar. University of Oslo; Noruega. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Collavini, Santiago. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina Fil: Lubell, James. University of Oslo; Noruega Fil: Llorens, Anaïs. University of Oslo; Noruega Fil: Funderud, Ingrid. University of Oslo; Noruega Fil: Ivanovic, Jugoslav. University of Oslo; Noruega Fil: Larsson, Pål G.. University of Oslo; Noruega Fil: Meling, Torstein R.. University of Oslo; Noruega Fil: Bekinschtein, Tristán Andrés. University of Cambridge; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Kochen, Sara Silvia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina Fil: Endestad, Tor. University of Oslo; Noruega Fil: Knight, Robert T.. University of California at Berkeley; Estados Unidos Fil: Solbakk, Anne Kristin. University of Oslo; Noruega