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Chronotype differences in cortical thickness: grey matter reflects when you go to bed
- Source :
- Brain Structure & Function, 223(7), 3411-3421. Springer
- Publication Year :
- 2018
- Publisher :
- Springer, 2018.
-
Abstract
- Based on individual circadian cycles and associated cognitive rhythms, humans can be classified via standardised self-reports as being early (EC), late (LC) and intermediate (IC) chronotypes. Alterations in neural cortical structure underlying these chronotype differences have rarely been investigated and are the scope of this study. 16 healthy male ECs, 16 ICs and 16 LCs were measured with a 3 T MAGNETOM TIM TRIO (Siemens, Erlangen) scanner using a magnetization prepared rapid gradient echo sequence. Data were analysed by applying voxel-based morphometry (VBM) and vertex-wise cortical thickness (CTh) analysis. VBM analysis revealed that ECs showed significantly lower grey matter volumes bilateral in the lateral occipital cortex and the precuneus as compared to LCs, and in the right lingual gyrus, occipital fusiform gyrus and the occipital pole as compared to ICs. CTh findings showed lower grey matter volumes for ECs in the left anterior insula, precuneus, inferior parietal cortex, and right pars triangularis than for LCs, and in the right superior parietal gyrus than for ICs. These findings reveal that chronotype differences are associated with specific neural substrates of cortical thickness, surface areas, and folding. We conclude that this might be the basis for chronotype differences in behaviour and brain function. Furthermore, our results speak for the necessity of considering "chronotype" as a potentially modulating factor in all kinds of structural brain-imaging experiments.
- Subjects :
- Activity Cycles
Male
Time Factors
Precuneus
computer.software_genre
Cognition
0302 clinical medicine
Voxel
Gray Matter
Brain Mapping
General Neuroscience
05 social sciences
Circadian
Human brain
HUMAN BRAIN
Magnetic Resonance Imaging
Circadian Rhythm
ALZHEIMERS-DISEASE
medicine.anatomical_structure
VEGETATIVE STATE
Female
Anatomy
Adult
Histology
Grey matter
Adolescent
Biology
SURFACE-BASED ANALYSIS
050105 experimental psychology
Cortical thickness
Young Adult
03 medical and health sciences
MAGNETIC-RESONANCE IMAGES
medicine
Humans
0501 psychology and cognitive sciences
Circadian rhythm
Life Style
Fusiform gyrus
Chronotype
GRAY-MATTER
Voxel-based morphometry
GEOMETRICALLY ACCURATE
FUNCTIONAL NEUROANATOMY
nervous system
Sleep
HUMAN CEREBRAL-CORTEX
Neuroscience
computer
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 18632661 and 18632653
- Volume :
- 223
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Brain Structure & Function
- Accession number :
- edsair.doi.dedup.....f72ee24a02517d4709efa02a1e398a59