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Hard-to-heal wound treated with Integra Flowable Wound Matrix: Analysis and clinical observations
- Publication Year :
- 2021
-
Abstract
- Skin healing defects severely impair the quality of life of millions of people and burden healthcare systems globally. The therapeutic approach to these pathologies still represents a challenge. Novel scaffolds, used as dermal substitutes, possibly represent a promising strategy in complex wound management. Integra Flowable Wound Matrix (IFWM) is composed of a lyophilised, micronised form of collagen/chondroitin sulphate matrix, already used in regenerative medicine and endorsed in the therapy of diabetic foot lesions. In this paper, IFWM was applied to a tunnelling hard-to-heal skin lesion in order to restore tissue integrity. Although the different phases of skin wound healing are well established, the molecular mechanism underpinning IFWM-induced tissue repair are almost unknown. Here, we report, for the first time, the comparative analysis of molecular, histological and clinical observations of the healing process of a hard-to-heal tunnelling skin wound. The therapeutic success of this clinical case allowed us to recommend the use of IFWM as a tissue substitute in this rare type of hard-to-heal wound in which the high inflammatory status hampered the natural healing process. Declaration of interest: The authors have no conflicts of interest.
- Subjects :
- medicine.medical_specialty
Nursing (miscellaneous)
Skin wound
Tunnelling skin wound
Diabete
Regenerative medicine
Chondroitin sulphate
Medicine
Humans
Ulcer
Dressing
Skin repair
Skin, Artificial
Clinical observation
Healing proce
Wound Healing
integumentary system
business.industry
Wound
Dermal substitute
medicine.disease
Diabetic foot
Molecular and histological analysi
Angiogenic proce
Diabetic Foot
Surgery
Wound management
Integra flowable wound matrix
Molecular mechanism
Quality of Life
Fundamentals and skills
Clinical case
Collagen
business
Infection
Delivery of Health Care
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f7267ead611fecf824c91d519bb98b0a