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The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them
- Source :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol 29, iss 10, Cancer Epidemiol Biomarkers Prev, Cancer Epidemiology Biomarkers & Prevention, 29(10), 1887-1903. American Association for Cancer Research Inc.
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- The key characteristics (KC) of human carcinogens provide a uniform approach to evaluating mechanistic evidence in cancer hazard identification. Refinements to the approach were requested by organizations and individuals applying the KCs. We assembled an expert committee with knowledge of carcinogenesis and experience in applying the KCs in cancer hazard identification. We leveraged this expertise and examined the literature to more clearly describe each KC, identify current and emerging assays and in vivo biomarkers that can be used to measure them, and make recommendations for future assay development. We found that the KCs are clearly distinct from the Hallmarks of Cancer, that interrelationships among the KCs can be leveraged to strengthen the KC approach (and an understanding of environmental carcinogenesis), and that the KC approach is applicable to the systematic evaluation of a broad range of potential cancer hazards in vivo and in vitro. We identified gaps in coverage of the KCs by current assays. Future efforts should expand the breadth, specificity, and sensitivity of validated assays and biomarkers that can measure the 10 KCs. Refinement of the KC approach will enhance and accelerate carcinogen identification, a first step in cancer prevention. See all articles in this CEBP Focus section, “Environmental Carcinogenesis: Pathways to Prevention.”
- Subjects :
- 0301 basic medicine
ARYL-HYDROCARBON RECEPTOR
IN-SILICO PREDICTION
Epidemiology
Computational biology
medicine.disease_cause
Medical and Health Sciences
Expert committee
Article
03 medical and health sciences
0302 clinical medicine
Neoplasms
Medicine
BREAST-CANCER
Humans
OXIDATIVE STRESS
Carcinogen
Cancer
Extramural
business.industry
Prevention
medicine.disease
eye diseases
REACTIVE METABOLITES
REPLICATION STRESS
CHROMOSOMAL-ABERRATIONS
030104 developmental biology
The Hallmarks of Cancer
Oncology
DNA-DAMAGE
030220 oncology & carcinogenesis
INFLAMMATORY BIOMARKERS
Environmental Carcinogenesis
Carcinogens
Identification (biology)
business
Carcinogenesis
Biomarkers
GENOMIC INSTABILITY
Subjects
Details
- ISSN :
- 10559965
- Database :
- OpenAIRE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol 29, iss 10, Cancer Epidemiol Biomarkers Prev, Cancer Epidemiology Biomarkers & Prevention, 29(10), 1887-1903. American Association for Cancer Research Inc.
- Accession number :
- edsair.doi.dedup.....f725ef5f94efc15e3ae91c735cca5fc4