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Prevalence of targeted therapy-related genetic variations in NSCLC and their relationship with clinicopathological characteristics
- Source :
- PLoS ONE, PLoS ONE, Vol 17, Iss 1, p e0262822 (2022), PLoS ONE, Vol 17, Iss 1 (2022)
- Publication Year :
- 2022
- Publisher :
- Public Library of Science, 2022.
-
Abstract
- Background Non-small cell lung cancer (NSCLC) is the most common cancer type in China. Targeted therapies have been used to treat NSCLC for two decades, which is only suitable for a subgroup of patients with specific genetic variations. The aim of this study was to investigate the prevalence of genetic variations leading to sensitivity or resistance to targeted therapies in NSCLC, and their relationship with clinicopathological characteristics of the patients. Methods Tumor samples were collected from 404 patients who were diagnosed to have NSCLC and underwent surgery, transthoracic biopsy, bronchoscopy biopsy, or pleural aspiration in Sichuan Provincial People’s Hospital from January 2019 to March 2020. Commercial amplification-refractory mutation system kits were used to detect targeted therapy-related genetic variations in those tumor samples. The prevalence of genetic variations and their relationship with patient clinicopathological characteristics were analyzed using statistical software, followed by subgroup analysis. Results In all, 50.7% of the NSCLC patients had sensitive genetic variations to anti-EGFR therapies, and 4.9% of those patients had co-existing resistant genetic variations. Fusions in ALK, ROS1, or RET were found in 7.7% of the patients, including 2 patients with co-existing EGFR exon 19 deletion or L858R. EGFR exon 19 deletion and L858R were more common in female patients and adenocarcinoma. Further subgroup analysis confirmed the observation in female patients in adenocarcinoma subgroup, and in adenocarcinoma in male patients. In addition, smokers were more likely to have squamous cell carcinoma and KRAS mutation and less likely to have EGFR L858R, which were also confirmed after standardization of gender except KRAS mutations. Conclusion Nearly half of the NSCLC patients were eligible for anti-EGFR treatments. In NSCLC, female gender and adenocarcinoma may indicate higher chance of EGFR exon 19 deletion or L858R, and smoking history may indicate squamous cell carcinoma and EGFR L858R.
- Subjects :
- Male
Lung Neoplasms
Science
Cancer Treatment
Adenocarcinoma of Lung
Adenocarcinoma
Lung and Intrathoracic Tumors
Malignant Tumors
Sex Factors
Carcinoma, Non-Small-Cell Lung
Medicine and Health Sciences
Genetics
Prevalence
Humans
Squamous Cell Carcinoma
Aged
Retrospective Studies
Evolutionary Biology
Multidisciplinary
Insertion Mutation
Population Biology
Carcinoma
Cancers and Neoplasms
Biology and Life Sciences
Human Genetics
Middle Aged
respiratory tract diseases
Non-Small Cell Lung Cancer
Neoplasm Proteins
Oncology
Mutation
Genetic Polymorphism
Medicine
Female
Population Genetics
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....f71f9b29b7f66b27b19ea7924e00cfd1