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Recombinant alpha-2 interferon gel treatment of recurrent herpes genitalis
- Source :
- Antiviral Research. 17:235-243
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- Topical recombinant alpha-2 interferon treatment of recurrent genital herpes was studied in a randomized, double-blind, placebo controlled clinical trial. Three hundred and eighty-seven patients were treated at eight study centers with either interferon gel or placebo four times daily for four days. Interferon therapy caused a 26% decrease in the duration of viral shedding. For male patients, there were also significant decreases in the time to crusting (17%) and duration of pain (34%) and itching (21%). For patients with recurrent genital herpes, treatment with topical interferon was found to be effective in decreasing the duration of viral shedding and, for males, pain, itching and time to crusting.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Alpha interferon
Administration, Cutaneous
Virus Replication
Placebo
Gastroenterology
Double-Blind Method
Recurrence
Interferon
Virology
Internal medicine
medicine
Humans
Viral shedding
skin and connective tissue diseases
Herpes Genitalis
Interferon alfa
Aged
Pharmacology
business.industry
Middle Aged
Recombinant Proteins
Interferon Type I
Immunology
Itching
Female
Viral disease
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 01663542
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Antiviral Research
- Accession number :
- edsair.doi.dedup.....f718d0a6be453b83b3e08b10a307f635