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Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6
- Source :
- Cell Death and Disease, Vol 12, Iss 2, Pp 1-13 (2021), Cell Death & Disease
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group, 2021.
-
Abstract
- A growing number of circular RNAs (circRNAs) have been identified and verified in several cancers. However, highly efficient therapeutic methods based on circRNAs in lung cancer remain largely unexplored. In the present study, we identified a novel circular RNA, hsa_circ_103820, based on Gene Expression Omnibus (GEO) data. Functionally, overexpression of hsa_circ_103820 showed significant inhibitory effects on the proliferation, migration and invasion of lung cancer cells, and knockdown of hsa_circ_103820 played promoting roles. Regarding the mechanism, we revealed that miR-200b-3p was a direct target of hsa_circ_103820 and that LATS2 and SOCS6 were the downstream target genes of miR-200b-3p. Therefore, we identified a novel potential tumor suppressive function of hsa_circ_103820 in lung cancer.
- Subjects :
- Male
Cancer Research
Lung Neoplasms
Carcinogenesis
Immunology
Suppressor of Cytokine Signaling Proteins
Protein Serine-Threonine Kinases
medicine.disease_cause
Article
Cellular and Molecular Neuroscience
Circular RNA
Cell Movement
medicine
Humans
SOCS6
Neoplasm Invasiveness
lcsh:QH573-671
Lung cancer
Gene
Cell Proliferation
Gene knockdown
Chemistry
lcsh:Cytology
Tumor Suppressor Proteins
Cell Biology
RNA, Circular
Middle Aged
medicine.disease
MicroRNAs
HEK293 Cells
A549 Cells
Cancer research
RNA
Female
Mir 200c
Non-small-cell lung cancer
Function (biology)
Subjects
Details
- Language :
- English
- ISSN :
- 20414889
- Volume :
- 12
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell Death and Disease
- Accession number :
- edsair.doi.dedup.....f7145acd7a0c3fc10fb9d12d0f0b42f6