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Randomised double-blind comparison of the incidence of tardive dyskinesia in patients with schizophrenia during long-term treatment with olanzapine or haloperidol
- Source :
- British Journal of Psychiatry. 174:23-30
- Publication Year :
- 1999
- Publisher :
- Royal College of Psychiatrists, 1999.
-
Abstract
- BackgroundTardive dyskinesia is important in the side-effect profile of antipsychotic medication.AimsThe development of tardive dyskinesia was evaluated in patients treated with double-blind, randomly assigned olanzapine or haloperidol for up to 2.6 years.MethodsTardive dyskinesia was assessed by the Abnormal Involuntary Movement Scale (AIMS) and Research Diagnostic Criteria for Tardive Dyskinesia (RD-TD); it was defined as meeting RD-TD criteria at two consecutive assessments. The risk of tardive dyskinesia, the relative risk, incidence rate, and incidence rate ratio were estimated.ResultsThe relative risk of tardive dyskinesia for the overall follow-up period for haloperidol (n=522) v. olanzapine (n=1192) was 2.66 (95% CI=1.50–4.70). Based on data following the initial six weeks of observation (during which patients underwent medication change and AIMS assessments as frequently as every three days), the one-year risk was 0.52% with olanzapine (n=513) and 7.45% with haloperidol (n=114). The relative risk throughout this follow-up period was 11.37 (95% Cl=2.21–58.60).ConclusionOur results indicated a significantly lower risk of tardive dyskinesia with olanzapine than with haloperidol.
- Subjects :
- Olanzapine
Dyskinesia, Drug-Induced
Pediatrics
medicine.medical_specialty
medicine.medical_treatment
050109 social psychology
Tardive dyskinesia
Rate ratio
Benzodiazepines
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Risk Factors
Haloperidol
Humans
Medicine
0501 psychology and cognitive sciences
Risk factor
Antipsychotic
business.industry
05 social sciences
Pirenzepine
medicine.disease
Survival Analysis
030227 psychiatry
Psychiatry and Mental health
Dyskinesia
Anesthesia
Schizophrenia
Abnormal Involuntary Movement Scale
medicine.symptom
business
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 14721465 and 00071250
- Volume :
- 174
- Database :
- OpenAIRE
- Journal :
- British Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....f70195253b5ea9e3c261484a971b8403