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The behavioral significance of coherent resting-state oscillations after stroke
- Source :
- NeuroImage, NeuroImage, Vol. 61, No 1 (2012) pp. 249-257
- Publication Year :
- 2012
-
Abstract
- Stroke lesions induce not only loss of local neural function, but disruptions in spatially distributed areas. However, it is unknown whether they affect the synchrony of electrical oscillations in neural networks and if changes in network coherence are associated with neurological deficits. This study assessed these questions in a population of patients with subacute, unilateral, ischemic stroke. Spontaneous cortical oscillations were reconstructed from high-resolution electroencephalograms (EEG) with adaptive spatial filters. Maps of functional connectivity (FC) between brain areas were created and correlated with patient performance in motor and cognitive scores. In comparison to age matched healthy controls, stroke patients showed a selective disruption of FC in the alpha frequency range. The spatial distribution of alpha band FC reflected the pattern of motor and cognitive deficits of the individual patient: network nodes that participate normally in the affected functions showed local decreases in FC with the rest of the brain. Interregional FC in the alpha band, but not in delta, theta, or beta frequencies, was highly correlated with motor and cognitive performance. In contrast, FC between contralesional areas and the rest of the brain was negatively associated with patient performance. Alpha oscillation synchrony at rest is a unique and specific marker of network function and linearly associated with behavioral performance. Maps of alpha synchrony computed from a single resting-state EEG recording provide a robust and convenient window into the functionality and organization of cortical networks with numerous potential applications.
- Subjects :
- Adult
Male
Cognitive Neuroscience
media_common.quotation_subject
Population
Alpha (ethology)
Electroencephalography
Functional Laterality
03 medical and health sciences
0302 clinical medicine
ddc:150
Neural Pathways
medicine
Image Processing, Computer-Assisted
Contrast (vision)
Humans
Attention
Effects of sleep deprivation on cognitive performance
education
Stroke
030304 developmental biology
media_common
Aged
Aged, 80 and over
0303 health sciences
education.field_of_study
Movement Disorders
medicine.diagnostic_test
Resting state fMRI
Hand Strength
Verbal Behavior
Cognition
Middle Aged
medicine.disease
Magnetic Resonance Imaging
ddc:616.8
Alpha Rhythm
Memory, Short-Term
Neurology
Data Interpretation, Statistical
Female
Psychology
Cognition Disorders
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10538119
- Volume :
- 61
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- NeuroImage
- Accession number :
- edsair.doi.dedup.....f700e05f614fed6f8032c32843f6a94d
- Full Text :
- https://doi.org/10.1016/j.neuroimage.2012.03.024