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Maternal Fat-1 Transgene Protects Offspring from Excess Weight Gain, Oxidative Stress, and Reduced Fatty Acid Oxidation in Response to High-Fat Diet
- Source :
- Nutrients, Volume 12, Issue 3, Nutrients, Vol 12, Iss 3, p 767 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Overweight and obesity accompanies up to 70% of pregnancies and is a strong risk factor for offspring metabolic disease. Maternal obesity-associated inflammation and lipid profile are hypothesized as important contributors to excess offspring liver and skeletal muscle lipid deposition and oxidative stress. Here, we tested whether dams expressing the fat-1 transgene, which endogenously converts omega-6 (n-6) to omega-3 (n-3) polyunsaturated fatty acid, could protect wild-type (WT) offspring against high-fat diet induced weight gain, oxidative stress, and disrupted mitochondrial fatty acid oxidation. Despite similar body mass at weaning, offspring from fat-1 high-fat-fed dams gained less weight compared with offspring from WT high-fat-fed dams. In particular, WT males from fat-1 high-fat-fed dams were protected from post-weaning high-fat diet induced weight gain, reduced fatty acid oxidation, or excess oxidative stress compared with offspring of WT high-fat-fed dams. Adult offspring of WT high-fat-fed dams exhibited greater skeletal muscle triglycerides and reduced skeletal muscle antioxidant defense and redox balance compared with offspring of WT dams on control diet. Fat-1 offspring were protected from the reduced fatty acid oxidation and excess oxidative stress observed in offspring of WT high-fat-fed dams. These results indicate that a maternal fat-1 transgene has protective effects against offspring liver and skeletal muscle lipotoxicity resulting from a maternal high-fat diet, particularly in males. Altering maternal fatty acid composition, without changing maternal dietary composition or weight gain with high-fat feeding, may highlight important strategies for n-3-based prevention of developmental programming of obesity and its complications.
- Subjects :
- 0301 basic medicine
Fatty Acid Desaturases
Male
medicine.medical_specialty
Antioxidant
Offspring
medicine.medical_treatment
030209 endocrinology & metabolism
Mice, Transgenic
lcsh:TX341-641
Biology
medicine.disease_cause
Diet, High-Fat
Article
03 medical and health sciences
Mice
0302 clinical medicine
Pregnancy
Internal medicine
medicine
Animals
Obesity
Transgenes
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Beta oxidation
fatty acid oxidation
chemistry.chemical_classification
Nutrition and Dietetics
Skeletal muscle
maternal obesity
Oxidative Stress
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Lipotoxicity
chemistry
Maternal Exposure
Female
medicine.symptom
omega-3
Weight gain
lcsh:Nutrition. Foods and food supply
metabolism
Oxidative stress
Food Science
Polyunsaturated fatty acid
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....f6f82dafca9f76e856cba86c1c80bfd2
- Full Text :
- https://doi.org/10.3390/nu12030767