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Comparison of biopsy strategies for prostate biopsy according to lesion size and PSA density in MRI-directed biopsy pathway
- Source :
- Abdominal Radiology. 45:4166-4177
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- To investigate whether the detection of clinically significant prostate cancer (csPCa) and the added value of focal saturation biopsy and systematic biopsy (SBx) differ according to index lesion size, and to compare the current guidelines for csPCa detection.This retrospective study included consecutive men who underwent MRI and subsequent SBx and MRI-targeted biopsy (TBx) for a suspicious lesion between April 2019 and February 2020. Lesion visibility on transrectal ultrasound (US) and added value of focal saturation biopsy and SBx were compared according to index lesion size using chi-square and McNemar tests. csPCa detection rates and the proportion of biopsy-indicated men were compared among four biopsy strategies based on current guidelines.Of 313 men evaluated (median age, 65; interquartile range 60‒71), csPCa was detected in 110 (35%). In lesions 10 mm, greater US invisibility (42.7% of lesions 10 mm versus 20.0% of lesions ≥ 10 mm; p 0.001) and higher added value of focal saturation biopsy and SBx (11.1% and 17.1% in lesions 10 mm versus 4.2% and 6.3% in lesions ≥ 10 mm) were observed, compared with lesions ≥ 10 mm. Consideration of prostate-specific antigen (PSA) density 0.15 ng/mL/mL as a cutoff in unsuspicious MRI led to a 14% reduction (44/313) in men who needed biopsy.Determination of the biopsy strategy in terms of the need for focal saturation biopsy or SBx should be made considering lesion size. The use of PSA density in non-suspicious MRI can lead to a reduction in biopsy-indicated men.
- Subjects :
- Image-Guided Biopsy
Male
medicine.medical_specialty
Prostate biopsy
Urology
030218 nuclear medicine & medical imaging
Lesion
03 medical and health sciences
Prostate cancer
0302 clinical medicine
McNemar's test
Interquartile range
Biopsy
medicine
Humans
Radiology, Nuclear Medicine and imaging
Aged
Retrospective Studies
Radiological and Ultrasound Technology
medicine.diagnostic_test
Index Lesion
business.industry
Prostate
Gastroenterology
Prostatic Neoplasms
Magnetic resonance imaging
Middle Aged
Prostate-Specific Antigen
medicine.disease
Magnetic Resonance Imaging
030220 oncology & carcinogenesis
Radiology
medicine.symptom
business
Subjects
Details
- ISSN :
- 23660058 and 2366004X
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Abdominal Radiology
- Accession number :
- edsair.doi.dedup.....f6d82d32392a7213feab324c1c03a597