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Viral pathogens hitchhike with insect sperm for paternal transmission
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019), Nature Communications
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Arthropod-borne viruses (arboviruses) can be maternally transmitted by female insects to their offspring, however, it is unknown whether male sperm can directly interact with the arbovirus and mediate its paternal transmission. Here we report that an important rice arbovirus is paternally transmitted by the male leafhoppers by hitchhiking with the sperm. The virus-sperm binding is mediated by the interaction of viral capsid protein and heparan sulfate proteoglycan on the sperm head surfaces. Mating experiments reveal that paternal virus transmission is more efficient than maternal transmission. Such paternal virus transmission scarcely affects the fitness of adult males or their offspring, and plays a pivotal role in maintenance of viral population during seasons unfavorable for rice hosts in the field. Our findings reveal that a preferred mode of vertical arbovirus transmission has been evolved by hitchhiking with insect sperm without disturbing sperm functioning, facilitating the long-term viral epidemic and persistence in nature.<br />Arbovirus vertical transmission is commonly mediated by transovarial passage of female insect vectors. Here, the authors show that Rice gall dwarf virus can be transmitted by male leafhoppers via interactions of the viral capsid and heparan sulfate proteoglycan on the surface of sperm heads.
- Subjects :
- Male
0301 basic medicine
viruses
General Physics and Astronomy
02 engineering and technology
Insect
Plant Viruses
law.invention
law
Mating
lcsh:Science
media_common
Genetics
education.field_of_study
Multidisciplinary
Maternal Transmission
food and beverages
021001 nanoscience & nanotechnology
Spermatozoa
Transmission (mechanics)
Insect Proteins
Female
0210 nano-technology
Offspring
Science
media_common.quotation_subject
Population
Biology
Reoviridae
Arbovirus
Article
General Biochemistry, Genetics and Molecular Biology
Hemiptera
03 medical and health sciences
medicine
Animals
Amino Acid Sequence
education
Plant Diseases
Host Microbial Interactions
Sequence Homology, Amino Acid
urogenital system
fungi
Oryza
General Chemistry
biochemical phenomena, metabolism, and nutrition
medicine.disease
Sperm
Insect Vectors
030104 developmental biology
lcsh:Q
Arboviruses
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....f6aef78b125526bbc0e3454b83d01b9e