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Mitophagy in carcinogenesis and cancer treatment
- Source :
- Discover Oncology, Vol 12, Iss 1, Pp 1-11 (2021), Discover. Oncology
- Publication Year :
- 2021
- Publisher :
- Springer, 2021.
-
Abstract
- In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namely mitophagy. This process can be induced through different pathways. The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be related to Parkinson’s disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins, such as BNIP3 and BNIP3L, also known as Nix. Through these two mechanisms, mitophagy fulfills its functions and maintains cellular homeostasis. Here, we summarize the current knowledge about the mechanisms of mitophagy regulation and their interplay with cancer progression as well as anticancer treatment.
- Subjects :
- Cancer Research
biology
Endocrine and Autonomic Systems
Mechanism (biology)
Endocrinology, Diabetes and Metabolism
Mitophagy
Cellular homeostasis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
PINK1
Review
medicine.disease_cause
Molecular medicine
Parkin
Cell biology
Endocrinology
Oncology
Ubiquitin
medicine
biology.protein
Autophagy
Homeostasis
Carcinogenesis
RC254-282
Cancer
Subjects
Details
- Language :
- English
- ISSN :
- 27306011
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Discover Oncology
- Accession number :
- edsair.doi.dedup.....f6a79f08a4b176844702360398341b6c