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Targeting inflammation in emerging therapies for genetic retinal disease
- Source :
- International Journal of Inflammation, International Journal of Inflammation, Vol 2013 (2013)
- Publication Year :
- 2012
-
Abstract
- Genetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. Diverse genetic abnormalities and environmental causes have been implicated in triggering multiple pathological mechanisms such as oxidative stress, lipofuscin deposits, neovascularisation, and programmed cell death. In recent years, inflammation has also been highlighted although whether inflammatory mediators play a central role in pathogenesis or a more minor secondary role has yet to be established. Despite this, numerous interventional studies, particularly targeting the complement system, are underway with the promise of novel therapeutic strategies for these important blinding conditions.
- Subjects :
- Pathology
medicine.medical_specialty
Programmed cell death
Inflammation
Disease
Review Article
Bioinformatics
Lipofuscin
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Retinitis pigmentosa
medicine
lcsh:Pathology
Immunology and Allergy
Pathological
030304 developmental biology
0303 health sciences
business.industry
Macular degeneration
medicine.disease
3. Good health
030221 ophthalmology & optometry
medicine.symptom
business
lcsh:RB1-214
Subjects
Details
- ISSN :
- 20908040
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- International journal of inflammation
- Accession number :
- edsair.doi.dedup.....f69bad81ba6fb608274e480800437626