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The Role of Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) in Radiation-Induced Tumor Cell Migration
- Publication Year :
- 2018
-
Abstract
- Recently it has been observed in preclinical models that that radiation enhances the recruitment of circulating tumor cells to primary tumors, and results in tumor regrowth after treatment. This process may have implications for clinical radiotherapy, which improves control of a number of tumor types but which, despite continued dose escalation and aggressive fractionation, is unable to fully prevent local recurrences. By irradiating a single tumor within an animal bearing multiple lesions, we observed an increase in tumor cell migration to irradiated and unirradiated sites, suggesting a systemic component to this process. Previous work has identified the cytokine GM-CSF, produced by tumor cells following irradiation, as a key effector of this process. We evaluated the ability of systemic injections of a PEGylated form of GM-CSF to stimulate tumor cell migration. While increases in invasion and migration were observed for tumor cells in a transwell assay, we found that daily injections of PEG-GM-CSF to tumor-bearing animals did not increase migration of cells to tumors, despite the anticipated changes in circulating levels of granulocytes and monocytes produced by this treatment. Combination of PEG-GM-CSF treatment with radiation also did not increase tumor cell migration. These findings suggest that clinical use of GM-CSF to treat neutropenia in cancer patients will not have negative effects on the aggressiveness of residual cancer cells. However, further work is needed to characterize the mechanism by which GM-CSF facilitates systemic recruitment of trafficking tumor cells to tumors.
- Subjects :
- 0301 basic medicine
Cancer Research
medicine.medical_treatment
Mice, Nude
Article
Metastasis
03 medical and health sciences
Mice
0302 clinical medicine
Circulating tumor cell
Surgical oncology
Cell Movement
Cell Line, Tumor
medicine
Animals
Neoplasm Invasiveness
business.industry
Cancer
Granulocyte-Macrophage Colony-Stimulating Factor
Mammary Neoplasms, Experimental
Cell migration
General Medicine
medicine.disease
Radiation therapy
030104 developmental biology
Granulocyte macrophage colony-stimulating factor
Cytokine
Oncology
030220 oncology & carcinogenesis
Cancer research
Female
business
Neoplasm Transplantation
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f696f327e9f7f7ed06300a258aa4e71f