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Herpes Simplex Virus 1 Upregulates p35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons
- Publication Year :
- 2015
- Publisher :
- American Society for Microbiology, 2015.
-
Abstract
- The cyclin-dependent kinase 5 (CDK-5) activating protein, p35, is important for acute herpes simplex virus 1 (HSV-1) replication in mice. This report shows that HSV-1 increases p35 levels, changes the primary localization of CDK-5 from the nucleus to the cytoplasm, and enhances CDK-5 activity during lytic or acute infection. Infected neurons also stained positive for the DNA damage response (DDR) marker γH2AX. We propose that CDK-5 is activated by the DDR to protect infected neurons from apoptosis.
- Subjects :
- DNA damage
viruses
Immunology
Cellular Response to Infection
Apoptosis
Herpesvirus 1, Human
Biology
medicine.disease_cause
Virus Replication
Microbiology
Histones
Cyclin-dependent kinase
Virology
medicine
Animals
Kinase activity
Mice, Knockout
Neurons
Kinase
Cyclin-dependent kinase 5
Phosphotransferases
Cyclin-Dependent Kinase 5
Molecular biology
Herpes simplex virus
Lytic cycle
Viral replication
nervous system
Insect Science
Host-Pathogen Interactions
biology.protein
biological phenomena, cell phenomena, and immunity
DNA Damage
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f68de74f846de4de0d3297b09523cde0