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Graph‐theoretical analysis of EEG functional connectivity during balance perturbation in traumatic brain injury: A pilot study
- Source :
- Human Brain Mapping
- Publication Year :
- 2021
- Publisher :
- John Wiley & Sons, Inc., 2021.
-
Abstract
- Traumatic brain injury (TBI) often results in balance impairment, increasing the risk of falls, and the chances of further injuries. However, the underlying neural mechanisms of postural control after TBI are not well understood. To this end, we conducted a pilot study to explore the neural mechanisms of unpredictable balance perturbations in 17 chronic TBI participants and 15 matched healthy controls (HC) using the EEG, MRI, and diffusion tensor imaging (DTI) data. As quantitative measures of the functional integration and segregation of the brain networks during the postural task, we computed the global graph‐theoretic network measures (global efficiency and modularity) of brain functional connectivity derived from source‐space EEG in different frequency bands. We observed that the TBI group showed a lower balance performance as measured by the center of pressure displacement during the task, and the Berg Balance Scale (BBS). They also showed reduced brain activation and connectivity during the balance task. Furthermore, the decrease in brain network segregation in alpha‐band from baseline to task was smaller in TBI than HC. The DTI findings revealed widespread structural damage. In terms of the neural correlates, we observed a distinct role played by different frequency bands: theta‐band modularity during the task was negatively correlated with the BBS in the TBI group; lower beta‐band network connectivity was associated with the reduction in white matter structural integrity. Our future studies will focus on how postural training will modulate the functional brain networks in TBI.<br />EEG connectivity graph measures were studied in traumatic brain injury (TBI) during the balance perturbation task. TBI group showed altered brain activation and connectivity during the balance task. Graph‐theoretic measures showed that the task modulation of brain network segregation in alpha‐band was reduced in TBI and the network segregation in theta‐band was associated with postural instability in TBI.
- Subjects :
- Adult
Male
medicine.medical_specialty
Traumatic brain injury
graph theory
Pilot Projects
Electroencephalography
postural control
White matter
Physical medicine and rehabilitation
Center of pressure (terrestrial locomotion)
Brain Injuries, Traumatic
medicine
Connectome
Humans
Radiology, Nuclear Medicine and imaging
Postural Balance
Research Articles
Balance (ability)
Neural correlates of consciousness
Radiological and Ultrasound Technology
Functional integration (neurobiology)
medicine.diagnostic_test
traumatic brain injury
balance perturbation
functional connectivity
Neurophysiology
Middle Aged
medicine.disease
Brain Waves
White Matter
EEG source localization
medicine.anatomical_structure
Diffusion Tensor Imaging
Neurology
Berg Balance Scale
Female
Neurology (clinical)
Anatomy
Psychology
Diffusion MRI
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 10970193 and 10659471
- Volume :
- 42
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Human Brain Mapping
- Accession number :
- edsair.doi.dedup.....f6864361d0a8830d8dac9c2a3c91609e