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IkappaB kinase signaling is essential for maintenance of mature B cells
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 2002
-
Abstract
- Nuclear factor (NF)-kappaB proteins play crucial roles in immune responses and cellular survival. Activation of NF-kappaB is mediated by the IkappaB kinase (IKK) complex, which is composed of two kinases, IKK1 and IKK2, and a regulatory subunit termed NF-kappaB essential modulator (NEMO). IKK2- and NEMO-deficient mice die at early embryonic stages. We therefore used conditional gene targeting to evaluate the role of these proteins in B cells in adult mice. B lineage-specific disruption of either IKK signaling by deletion of NEMO, or of IKK2-specific signals by ablation of IKK2 activity leads to the disappearance of mature B lymphocytes. We conclude that maintenance of mature B cells depends on IKK-mediated activation of NF-kappaB.
- Subjects :
- Protein subunit
Immunology
Antigens, CD19
B cell subsets
IκB kinase
Biology
Protein Serine-Threonine Kinases
Article
NF-κB
maintenance
Mice
Viral Proteins
Immunology and Allergy
Animals
CHUK
skin and connective tissue diseases
B-Lymphocytes
Integrases
Kinase
IKK
CD19-Cre
I-Kappa-B Kinase
NF-kappa B
Gene targeting
NFKB1
Flow Cytometry
Molecular biology
Cell biology
I-kappa B Kinase
Signal transduction
Subjects
Details
- ISSN :
- 00221007
- Volume :
- 196
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The Journal of experimental medicine
- Accession number :
- edsair.doi.dedup.....f684693dc4ee05bc9c6d41fb3210a74e