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Differences Between d-Fenfluramine and d-Norfenfluramine in Serotonin Presynaptic Mechanisms
- Source :
- Journal of Neurochemistry. 40:891-893
- Publication Year :
- 1983
- Publisher :
- Wiley, 1983.
-
Abstract
- The abilities of d-fenfluramine (d-F) and that of d-norfenfluramine (d-NF) to inhibit [3H]serotonin ([3H]5-HT) accumulation in normal and reserpinized synaptosomes were compared to establish to what extent the serotonin-releasing activity of the two drugs might contribute to reduced accumulation of [3H]5-HT. The results indicate that the inhibitory action of (d-NF) on [3H]5-HT accumulation is due principally to its ability to release [3H]5-HT. In contrast, the interference of release in accumulation studies does not seem to play an important role for d-F, suggesting that release from the granular pool and true uptake inhibition are two different mechanisms by which d-F affects serotonin neurons in vitro.
- Subjects :
- Serotonin
medicine.medical_specialty
Reserpine
Fenfluramine
Biology
Pharmacology
Inhibitory postsynaptic potential
Biochemistry
D norfenfluramine
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Norfenfluramine
Internal medicine
medicine
Animals
Dose-Response Relationship, Drug
Brain
In vitro
Rats
Endocrinology
chemistry
Synaptosomes
medicine.drug
Subjects
Details
- ISSN :
- 14714159 and 00223042
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Journal of Neurochemistry
- Accession number :
- edsair.doi.dedup.....f6804dc288744f35ec81daf4ad9d6e6d