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Effect of Blood Volume Shift Simulated via Head-up Tilt on Photoplethysmography Morphology
- Source :
- EMBC
- Publication Year :
- 2020
-
Abstract
- PPG can provide information on cardiovascular responses to fluid shifts from upper to lower part of body under the condition of orthostatic stress. The current study investigated ability of PPG derived LVET and other PPG derived features to identify progressive central hypovolemia induced by head up tilt (HUT) and evaluated potential use of LVET as early noninvasive indicator of blood loss. Continuous finger PPG, blood pressure, and electrocardiography were recorded simultaneously during 5-minutes of baseline and HUT of 20°, 40°, and 60° from 15 participants (age: 26.5 ± 3 years; height: 177 ± 8 cm; weight: 72 ± 10 kg, mean ± SD). Beat-by-beat pulse rate (PR), systolic amplitude (SA), systolic time (ST), diastolic time (DT), and PP Interval (PPI) and Ratio of pulse rate over systolic amplitude (PR/SA) were derived for each stage. LVET was derived from each stage. Friedman test followed by post-hoc analysis using Tukey-HSD was conducted to highlight the significance of changes induced by HUT. Application of 60° HUT (i.e. moderate category simulated hypovolemia) resulted in a significant change in PR (80±3 bpm vs 68±3 bpm, p=0.0008), DT (264±7 ms vs 303±4 ms, p=0.0008), ST (110±6 ms vs 117±7 ms, p=0.02), PP interval (764±39 ms vs 869±25 ms, p=0.0045), PR/SA (112±16 vs 82±21, p=0.012) , SA (0.875± 0.2 vs 1.69±0.6, p=0.012) and LVET(292 vs 351ms,p=0.0008) compared to baseline. LVET has a strong association with the change in central blood volume and may be used as a sensitive early marker of progressive hypovolemia. The findings of the study support the hypothesis of differentiating simulated hypovolemia based on PPG alone. Keywords: Hypovolemia, HUT, LVET.
- Subjects :
- 030110 physiology
0301 basic medicine
Adult
medicine.medical_specialty
Systole
Hypovolemia
Diastole
Blood volume
03 medical and health sciences
Young Adult
0302 clinical medicine
Heart Rate
Photoplethysmogram
Internal medicine
Medicine
Humans
Photoplethysmography
Blood Volume
medicine.diagnostic_test
business.industry
030208 emergency & critical care medicine
Head up tilt
PP interval
Blood pressure
Cardiology
medicine.symptom
business
Electrocardiography
Subjects
Details
- ISSN :
- 26940604
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
- Accession number :
- edsair.doi.dedup.....f679edbddf21f5cb2e5fc0e1467c23cd