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Imipramine reverses alterations in cytokines and BDNF levels induced by maternal deprivation in adult rats
- Source :
- Behavioural brain research. 242
- Publication Year :
- 2012
-
Abstract
- A growing body of evidence is pointing toward an association between immune molecules, as well brain-derived neurotrophic factor (BDNF) and the depression. The present study was aimed to evaluate the behavioral and molecular effects of the antidepressant imipramine in maternally deprived adult rats. To this aim, maternally deprived and non-deprived (control group) male rats were treated with imipramine (30mg/kg) once a day for 14 days during their adult phase. Their behavior was then assessed using the forced swimming test. In addition to this, IL-10, TNF-α and IL-1β cytokines were assessed in the serum and cerebrospinal fluid (CSF). In addition, BDNF protein levels were assessed in the prefrontal cortex, hippocampus and amygdala. In deprived rats treated with saline was observed an increase on immobility time, compared with non-deprived rats treated with imipramine (p
- Subjects :
- Male
medicine.medical_specialty
Imipramine
Antidepressive Agents, Tricyclic
Amygdala
Behavioral Neuroscience
Neurotrophic factors
Pregnancy
Internal medicine
medicine
Hippocampus (mythology)
Animals
Rats, Wistar
Maternal deprivation
Analysis of Variance
biology
Brain-Derived Neurotrophic Factor
Maternal Deprivation
Brain
Rats
medicine.anatomical_structure
Endocrinology
Gene Expression Regulation
biology.protein
Antidepressant
Cytokines
Female
Psychology
Behavioural despair test
medicine.drug
Neurotrophin
Subjects
Details
- ISSN :
- 18727549
- Volume :
- 242
- Database :
- OpenAIRE
- Journal :
- Behavioural brain research
- Accession number :
- edsair.doi.dedup.....f66a7a5fd13eb07bf52d800f8d67ec1a