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Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF-κB Activation
- Source :
- Planta medica. 88(11)
- Publication Year :
- 2021
-
Abstract
- Three new flavanols, (2R,3S)-7-methoxy-flavan-3-ol (1), (2R,3S)-7-hydroxy-flavan-3-ol (2), and (2R,3S)-2′-hydroxy-7-methoxy-flavan-3-ol (3), together with two known flavans (4 and 5), were isolated from the chloroform extract of Crinum asiaticum. Their structures were elucidated by various spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and CD data. The isolated compounds 1 and 3−5 showed inhibitory activity toward LPS-induced nitric oxide (NO) production. Further investigation of the NF-κB pathway mechanisms indicated that 1 and 3−5 inhibited the LPS-induced IL-6 production and p65 subunit phosphorylation of NF-κB in RAW264.7 cells, with an effective dose of 10 µM.
- Subjects :
- Lipopolysaccharides
Protein subunit
Pharmaceutical Science
Nitric Oxide Synthase Type II
Pharmacology
Inhibitory postsynaptic potential
Nitric Oxide
Analytical Chemistry
Nitric oxide
chemistry.chemical_compound
Mice
Crinum asiaticum
Drug Discovery
Animals
Flavonoids
biology
Chemistry
Organic Chemistry
NF-kappa B
Polyphenols
biology.organism_classification
Effective dose (pharmacology)
RAW 264.7 Cells
Complementary and alternative medicine
Crinum
Molecular Medicine
Phosphorylation
Signal transduction
Two-dimensional nuclear magnetic resonance spectroscopy
Signal Transduction
Subjects
Details
- ISSN :
- 14390221
- Volume :
- 88
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Planta medica
- Accession number :
- edsair.doi.dedup.....f66a279265d5f47eaa8843c8b9efcca1