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Medium-Term Outcomes in Severely to Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection
- Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
- Publication Year :
- 2021
-
Abstract
- Background The medium- and long-term effects of severe acute respiratory syndrome coronavirus 2 infection on survivors are unknown. In the current study, we assessed the medium-term effects of coronavirus disease 2019 (COVID-19) on survivors of severe disease. Methods This is a retrospective, case series of 200 patients hospitalized across 3 large Birmingham hospitals with severe-to-critical COVID-19 infection 4–7 months from disease onset. Patients underwent comprehensive clinical, laboratory, imaging, lung function tests (LFTs), and quality of life and cognitive assessments. Results At 4–7 months after disease onset, 63.2% of patients reported persistent breathlessness; 53.5%, significant fatigue; 37.5%, reduced mobility; and 36.8% pain. Serum markers of inflammation and organ injuries that persisted at hospital discharge had normalized on follow-up, indicating no sustained immune response causing chronic maladaptive inflammation. Chest radiographs showed complete resolution in 82.8%, and significant improvement or no change in 17.2%. LFTs revealed gas transfer abnormalities in 80.0% and abnormal spirometric values in 37.6% of patients. Compared with patients who did not experience breathlessness, those who did had significantly higher incidences of comorbid conditions and residual chest radiographic and LFT abnormalities (P Conclusions A significant proportion of severely ill patients with COVID-19 still experience symptoms of breathlessness, fatigue, pain, reduced mobility, depression and reduced quality of life 4–7 months after disease onset. Symptomatic patients tend to have more residual chest radiographic and LFT abnormalities.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Spirometry
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Radiography
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Critical Illness
030106 microbiology
Medium term
Pulmonary function testing
03 medical and health sciences
0302 clinical medicine
Quality of life
Internal medicine
medicine
Major Article
Humans
030212 general & internal medicine
Depression (differential diagnoses)
Retrospective Studies
medicine.diagnostic_test
business.industry
SARS-CoV-2
COVID-19
Coronavirus
Infectious Diseases
AcademicSubjects/MED00290
Quality of Life
business
Subjects
Details
- ISSN :
- 15376591
- Volume :
- 74
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Accession number :
- edsair.doi.dedup.....f650e9213425899f88de47e00c50291f