Back to Search
Start Over
Oral and Oropharyngeal squamous cell carcinoma: prognostic and predictive parameters in the etiopathogenetic route
- Source :
- Expert Review of Anticancer Therapy. 19:105-119
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Introduction: Oral and oropharyngeal squamous cell carcinoma (OSCC and OPSCC) represents an increasing problem in the global public health. Indeed, squamous cell carcinoma is the most frequent malignancy in oral cavity and 1 of the 10 most common cancers worldwide. According to the most recent GLOBOCAN estimate in Europe between 2012 and 2015, there was an overall increasing incidence and mortality for oral cancer, mostly HPV-related in the oropharyngeal region with evidence of significant differences from the prognostic and therapeutic point of view. Areas covered: Until now, the management of the patients is based on classical histologic parameters such as TNM and tumor grading, but new molecular and cell markers have been investigated to improve patients’ treatment and survival. Therefore, there is a need for new biomarkers characterizing the cancer diversity, with the consequent possibility of patient stratification for specific treatment. Expert commentary: This review aims to discuss some of the most relevant and novel genetic, epigenetic, and histological prognostic biomarkers in oral cancer, highlighting the main differences between HPV-unrelated oral squamous cell carcinoma (OSCC) and HPV-related oropharyngeal squamous cell carcinoma (OPSCC) that may aid in stratifying prognostic subgroups and rationalizing treatment decisions. Introduction: Oral and oropharyngeal squamous cell carcinoma (OSCC and OPSCC) represents an increasing problem in the global public health. Indeed, squamous cell carcinoma is the most frequent malignancy in oral cavity and 1 of the 10 most common cancers worldwide. According to the most recent GLOBOCAN estimate in Europe between 2012 and 2015, there was an overall increasing incidence and mortality for oral cancer, mostly HPV-related in the oropharyngeal region with evidence of significant differences from the prognostic and therapeutic point of view. Areas covered: Until now, the management of the patients is based on classical histologic parameters such as TNM and tumor grading, but new molecular and cell markers have been investigated to improve patients’ treatment and survival. Therefore, there is a need for new biomarkers characterizing the cancer diversity, with the consequent possibility of patient stratification for specific treatment. Expert commentary: This review aims to discuss some of the most relevant and novel genetic, epigenetic, and histological prognostic biomarkers in oral cancer, highlighting the main differences between HPV-unrelated oral squamous cell carcinoma (OSCC) and HPV-related oropharyngeal squamous cell carcinoma (OPSCC) that may aid in stratifying prognostic subgroups and rationalizing treatment decisions.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
EGFR
orapharyngeal squamous cell carcinoma
03 medical and health sciences
0302 clinical medicine
PDL1
Internal medicine
parasitic diseases
Biomarkers, Tumor
Humans
Medicine
Pharmacology (medical)
Basal cell
Oropharyngeal squamous cell carcinoma
Human papilloma virus
Squamous Cell Carcinoma of Head and Neck
business.industry
Papillomavirus Infections
Prognosis
oral squamous cell carcinoma
Oropharyngeal Neoplasms
stomatognathic diseases
030104 developmental biology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Mouth Neoplasms
Neoplasm Grading
business
human papilloma viru
Subjects
Details
- ISSN :
- 17448328 and 14737140
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Expert Review of Anticancer Therapy
- Accession number :
- edsair.doi.dedup.....f650dbcb57d0fb0c16b2ce208c4d6e55