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Predicting fracture healing with blood biomarkers: the potential to assess patient risk of fracture nonunion
- Source :
- Biomarkers. 26:703-717
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Fracture non-union is a significant orthopaedic problem affecting a substantial number of patients yearly. Treatment of nonunions is devastating to patients and costly to the healthcare system. Unfortunately, the diagnosis of non-union is typically made in a reactionary fashion by an orthopaedic surgeon based on clinical assessment and radiographic features several months into treatment. For this reason, investigators have been trying to develop prediction algorithms; however, these have relied on population-based approaches and lack the predictive capability necessary to make individual treatment decisions. There is also a growing body of literature focussed on identifying blood biomarkers that are associated with non-union. This review describes the research that has been done in this area. Further studies of patient-centered, precision medicine approaches will likely improve fracture non-union diagnostic/prognostic capabilities.
- Subjects :
- medicine.medical_specialty
Time Factors
Health, Toxicology and Mutagenesis
Patient risk
Osteocalcin
Clinical Biochemistry
Nonunion
Population
Bone healing
Risk Assessment
Biochemistry
Collagen Type I
Predictive Value of Tests
Risk Factors
medicine
Humans
Intensive care medicine
education
Fracture Healing
education.field_of_study
business.industry
Alkaline Phosphatase
Prognosis
Precision medicine
medicine.disease
Peptide Fragments
Blood biomarkers
Fractures, Ununited
Orthopedic surgery
Cytokines
Intercellular Signaling Peptides and Proteins
Peptides
business
Biomarkers
Procollagen
Fracture nonunion
Subjects
Details
- ISSN :
- 13665804 and 1354750X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Biomarkers
- Accession number :
- edsair.doi.dedup.....f64e280b84044760c80889112a0b90ce