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Pathophysiology of axial spondyloarthritis: Consensus and controversies
- Source :
- European Journal of Clinical Investigation, 48(5)
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background Axial spondyloarthritis (axSpA) is a common inflammatory arthritis of the sacroiliac joints and the spine. The best-known and most studied form of axSpA is ankylosing spondylitis. Design In this review, we provide a brief overview of the pathophysiology of axSpA. In addition, we performed a quantitative text analysis of reviews on the pathogenesis of axSpA published in the last 10 years to establish the current consensus in various fields of research into the pathogenesis of axSpA. Results There appears to be broad consensus on genetic risk factors and the involvement of the immune system in the initiation phase of the disease although little consensus was found on which specific immune cells drive disease. Moreover, despite relatively little data available, alterations in the microbiome are commonly thought to be involved in disease. Abnormal bone formation is the most prominent pathogenic factor thought to be involved in disease progression. Conclusion So, although the pathophysiology of axSpA remains incompletely understood, the progress in recent years in several fields of research in axSpA including genetics, diagnosis, imaging and therapeutics, hold great promise for the future.
- Subjects :
- 0301 basic medicine
Inflammatory arthritis
Clinical Biochemistry
Disease
Bioinformatics
Biochemistry
03 medical and health sciences
0302 clinical medicine
Osteogenesis
Risk Factors
Spondylarthritis
Humans
Medicine
Genetic Predisposition to Disease
Spondylitis, Ankylosing
Bone formation
Genetic risk
Axial spondyloarthritis
HLA-B27 Antigen
030203 arthritis & rheumatology
Ankylosing spondylitis
business.industry
Arthritis
pathogenesis
Pathogenic factor
early disease
Sacroiliac Joint
axial spondyloarthritis
General Medicine
medicine.disease
Pathophysiology
030104 developmental biology
Stress, Mechanical
business
Subjects
Details
- ISSN :
- 00142972
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....f645ea7e0140eb94e6ba3aae714d13d0