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Chlorogenic acid activates ERK1/2 and inhibits proliferation of osteosarcoma cells
- Source :
- Journal of cellular physiology. 235(4)
- Publication Year :
- 2019
-
Abstract
- Osteosarcoma (OS) is a very aggressive metastatic pediatric and adolescent tumor. Due to its recurrent development of chemotherapy resistance, clinical outcome for OS patients remains poor. Therefore, discovering more effective anticancer agents is needed. Chlorogenic acid (CGA) is a phenolic compound contained in plant-related products that modulates many cellular functions and inhibits cell proliferation in several cancer types. However, few evidence is available in OS. Here, we investigate the effects of CGA in U2OS, Saos-2, and MG-63 OS cells. By multiple approaches, we demonstrate that CGA acts as anticancer molecule affecting the cell cycle and provoking cell growth inhibition mainly by apoptosis induction. We also provide evidence that CGA strongly activates extracellular-signal-regulated kinase1/2 (ERK1/2). Strikingly, ERK1/2 inhibitor PD98059 sensitizes the cells to CGA. Altogether, our data enforce the evidence of the anticancer activity mediated by CGA and provide the rationale for the development of innovative therapeutic strategies in OS cure.
- Subjects :
- 0301 basic medicine
Male
endocrine system
Adolescent
Physiology
Cell Survival
MAP Kinase Signaling System
Clinical Biochemistry
Cellular functions
Antineoplastic Agents
Apoptosis
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Chlorogenic acid
Cell Line, Tumor
medicine
Animals
Humans
ERK1/2 pathway
Child
antitumor
Cell Proliferation
Flavonoids
Osteosarcoma
Mitogen-Activated Protein Kinase 3
Cell growth
Cell Cycle
Cancer
Cell Biology
Cell cycle
Middle Aged
medicine.disease
Apoptosis induction
apoptosi
030104 developmental biology
chemistry
PD98059
Drug Resistance, Neoplasm
030220 oncology & carcinogenesis
Cancer research
NIH 3T3 Cells
Female
Chlorogenic Acid
Subjects
Details
- ISSN :
- 10974652
- Volume :
- 235
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of cellular physiology
- Accession number :
- edsair.doi.dedup.....f64257d9ea7eb7a73fdf3b970d795dd0