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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Authors :
Christopher J. Ricketts Aguirre A. De Cubas Huihui Fan Christof C. Smith Martin Lang Ed Reznik Reanne Bowlby Ewan A. Gibb Rehan Akbani Rameen Beroukhim Donald P. Bottaro Toni K. Choueiri Richard A. Gibbs Andrew K. Godwin Scott Haake A. Ari Hakimi Elizabeth P. Henske James J. Hsieh Thai H. Ho Rupa S. Kanchi Bhavani Krishnan David J. Kwiatkowski Wembin Lui Maria J. Merino Gordon B. Mills Jerome Myers Michael L. Nickerson Victor E. Reuter Laura S. Schmidt C. Simon Shelley Hui Shen Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Benjamin G. Vincent Cathy D. Vocke David A. Wheeler Lixing Yang William Y. Kim A. Gordon Robertson Paul T. Spellman W. Kimryn Rathmell W. Marston Linehan Samantha J. Caesar-Johnson John A. Demchok Ina Felau Melpomeni Kasapi Martin L. Ferguson Carolyn M. Hutter Heidi J. Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C. Zenklusen Jiashan (Julia) Zhang Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Juok Cho Timothy DeFreitas Scott Frazer Nils Gehlenborg Gad Getz David I. Heiman Jaegil Kim Michael S. Lawrence Pei Lin Sam Meier Michael S. Noble Gordon Saksena Doug Voet Hailei Zhang Brady Bernard Nyasha Chambwe Varsha Dhankani Theo Knijnenburg Roger Kramer Kalle Leinonen Yuexin Liu Michael Miller Sheila Reynolds Ilya Shmulevich Vesteinn Thorsson Wei Zhang Bradley M. Broom Apurva M. Hegde Zhenlin Ju Anil Korkut Jun Li Han Liang Shiyun Ling Wenbin Liu Yiling Lu Kwok-Shing Ng Arvind Rao Michael Ryan Jing Wang John N. Weinstein Jiexin Zhang Adam Abeshouse Joshua Armenia Debyani Chakravarty Walid K. Chatila Ino de Bruijn Jianjiong Gao Benjamin E. Gross Zachary J. Heins Ritika Kundra Konnor La Marc Ladanyi Augustin Luna Moriah G. Nissan Angelica Ochoa Sarah M. Phillips Francisco Sanchez-Vega Chris Sander Nikolaus Schultz Robert Sheridan S. Onur Sumer Yichao Sun Barry S. Taylor Jioajiao Wang Hongxin Zhang Pavana Anur Myron Peto Paul Spellman Christopher Benz Joshua M. Stuart Christopher K. Wong Christina Yau D. Neil Hayes Joel S. Parker Matthew D. Wilkerson Adrian Ally Miruna Balasundaram Denise Brooks Rebecca Carlsen Eric Chuah Noreen Dhalla Robert Holt Steven J.M. Jones Katayoon Kasaian Darlene Lee Yussanne Ma Marco A. Marra Michael Mayo Richard A. Moore Andrew J. Mungall Karen Mungall Sara Sadeghi Jacqueline E. Schein Payal Sipahimalani Angela Tam Nina Thiessen Kane Tse Tina Wong Ashton C. Berger Andrew D. Cherniack Carrie Cibulskis Stacey B. Gabriel Galen F. Gao Gavin Ha Matthew Meyerson Steven E. Schumacher Juliann Shih Melanie H. Kucherlapati Raju S. Kucherlapati Stephen Baylin Leslie Cope Ludmila Danilova Moiz S. Bootwalla Phillip H. Lai Dennis T. Maglinte David J. Van Den Berg Daniel J. Weisenberger J. Todd Auman Saianand Balu Tom Bodenheimer Cheng Fan Katherine A. Hoadley Alan P. Hoyle Stuart R. Jefferys Corbin D. Jones Shaowu Meng Piotr A. Mieczkowski Lisle E. Mose Amy H. Perou Charles M. Perou Jeffrey Roach Yan Shi Janae V. Simons Tara Skelly Matthew G. Soloway Donghui Tan Umadevi Veluvolu Toshinori Hinoue Peter W. Laird Wanding Zhou Michelle Bellair Kyle Chang Kyle Covington Chad J. Creighton Huyen Dinh HarshaVardhan Doddapaneni Lawrence A. Donehower Jennifer Drummond Robert Glenn Walker Hale Yi Han Jianhong Hu Viktoriya Korchina Sandra Lee Lora Lewis Wei Li Xiuping Liu Margaret Morgan Donna Morton Donna Muzny Jireh Santibanez Margi Sheth Eve Shinbrot Linghua Wang Min Wang Liu Xi Fengmei Zhao Julian Hess Elizabeth L. Appelbaum Matthew Bailey Matthew G. Cordes Li Ding Catrina C. Fronick Lucinda A. Fulton Robert S. Fulton Cyriac Kandoth Elaine R. Mardis Michael D. McLellan Christopher A. Miller Heather K. Schmidt Richard K. Wilson Daniel Crain Erin Curley Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Candace Shelton Troy Shelton Mark Sherman Eric Thompson Peggy Yena Jay Bowen Julie M. Gastier-Foster Mark Gerken Kristen M. Leraas Tara M. Lichtenberg Nilsa C. Ramirez Lisa Wise Erik Zmuda Niall Corcoran Tony Costello Christopher Hovens Andre L. Carvalho Ana C. de Carvalho José H. Fregnani Adhemar Longatto-Filho Rui M. Reis Cristovam Scapulatempo-Neto Henrique C.S. Silveira Daniel O. Vidal Andrew Burnette Jennifer Eschbacher Beth Hermes Ardene Noss Rosy Singh Matthew L. Anderson Patricia D. Castro Michael Ittmann David Huntsman Bernard Kohl Xuan Le Richard Thorp Chris Andry Elizabeth R. Duffy Vladimir Lyadov Oxana Paklina Galiya Setdikova Alexey Shabunin Mikhail Tavobilov Christopher McPherson Ronald Warnick Ross Berkowitz Daniel Cramer Colleen Feltmate Neil Horowitz Adam Kibel Michael Muto Chandrajit P. Raut Andrei Malykh Jill S. Barnholtz-Sloan Wendi Barrett Karen Devine Jordonna Fulop Quinn T. Ostrom Kristen Shimmel Yingli Wolinsky Andrew E. Sloan Agostino De Rose Felice Giuliante Marc Goodman Beth Y. Karlan Curt H. Hagedorn John Eckman Jodi Harr Kelinda Tucker Leigh Anne Zach Brenda Deyarmin Hai Hu Leonid Kvecher Caroline Larson Richard J. Mural Stella Somiari Ales Vicha Tomas Zelinka Joseph Bennett Mary Iacocca Brenda Rabeno Patricia Swanson Mathieu Latour Louis Lacombe Bernard Têtu Alain Bergeron Mary McGraw Susan M. Staugaitis John Chabot Hanina Hibshoosh Antonia Sepulveda Tao Su Timothy Wang Olga Potapova Olga Voronina Laurence Desjardins Odette Mariani Sergio Roman-Roman Xavier Sastre Marc-Henri Stern Feixiong Cheng Andrew Berchuck Darell Bigner Eric Lipp Jeffrey Marks Shannon McCall Roger McLendon Angeles Secord Alexis Sharp Madhusmita Behera Daniel J. Brat Amy Chen Keith Delman Seth Force Fadlo Khuri Kelly Magliocca Shishir Maithel Jeffrey J. Olson Taofeek Owonikoko Alan Pickens Suresh Ramalingam Dong M. Shin Gabriel Sica Erwin G. Van Meir Hongzheng Zhang Wil Eijckenboom Ad Gillis Esther Korpershoek Leendert Looijenga Wolter Oosterhuis Hans Stoop Kim E. van Kessel Ellen C. Zwarthoff Chiara Calatozzolo Lucia Cuppini Stefania Cuzzubbo Francesco DiMeco Gaetano Finocchiaro Luca Mattei Alessandro Perin Bianca Pollo Chu Chen John Houck Pawadee Lohavanichbutr Arndt Hartmann Christine Stoehr Robert Stoehr Helge Taubert Sven Wach Bernd Wullich Witold Kycler Dawid Murawa Maciej Wiznerowicz Ki Chung W. Jeffrey Edenfield Julie Martin Eric Baudin Glenn Bubley Raphael Bueno Assunta De Rienzo William G. Richards Steven Kalkanis Tom Mikkelsen Houtan Noushmehr Lisa Scarpace Nicolas Girard Marta Aymerich Elias Campo Eva Giné Armando López Guillermo Nguyen Van Bang Phan Thi Hanh Bui Duc Phu Yufang Tang Howard Colman Kimberley Evason Peter R. Dottino John A. Martignetti Hani Gabra Hartmut Juhl Teniola Akeredolu Serghei Stepa Dave Hoon Keunsoo Ahn Koo Jeong Kang Felix Beuschlein Anne Breggia Michael Birrer Debra Bell Mitesh Borad Alan H. Bryce Erik Castle Vishal Chandan John Cheville John A. Copland Michael Farnell Thomas Flotte Nasra Giama Thai Ho Michael Kendrick Jean-Pierre Kocher Karla Kopp Catherine Moser David Nagorney Daniel O’Brien Brian Patrick O’Neill Tushar Patel Gloria Petersen Florencia Que Michael Rivera Lewis Roberts Robert Smallridge Thomas Smyrk Melissa Stanton R. Houston Thompson Michael Torbenson Ju Dong Yang Lizhi Zhang Fadi Brimo Jaffer A. Ajani Ana Maria Angulo Gonzalez Carmen Behrens Jolanta Bondaruk Russell Broaddus Bogdan Czerniak Bita Esmaeli Junya Fujimoto Jeffrey Gershenwald Charles Guo Alexander J. Lazar Christopher Logothetis Funda Meric-Bernstam Cesar Moran Lois Ramondetta David Rice Anil Sood Timothy Thompson Patricia Troncoso Anne Tsao Ignacio Wistuba Candace Carter Lauren Haydu Peter Hersey Valerie Jakrot Hojabr Kakavand Richard Kefford Kenneth Lee Georgina Long Graham Mann Michael Quinn Robyn Saw Richard Scolyer Kerwin Shannon Andrew Spillane onathan Stretch Maria Synott John Thompson James Wilmott Hikmat Al-Ahmadie Timothy A. Chan Ronald Ghossein Anuradha Gopalan Douglas A. Levine Victor Reuter Samuel Singer Bhuvanesh Singh Nguyen Viet Tien Thomas Broudy Cyrus Mirsaidi Praveen Nair Paul Drwiega Judy Miller Jennifer Smith Howard Zaren Joong-Won Park Nguyen Phi Hung Electron Kebebew Adam R. Metwalli Karel Pacak Peter A. Pinto Mark Schiffman Nicolas Wentzensen Robert Worrell Hannah Yang Marc Moncrieff Chandra Goparaju Jonathan Melamed Harvey Pass Natalia Botnariuc Irina Caraman Mircea Cernat Inga Chemencedji Adrian Clipca Serghei Doruc Ghenadie Gorincioi Sergiu Mura Maria Pirtac Irina Stancul Diana Tcaciuc Monique Albert Iakovina Alexopoulou Angel Arnaout John Bartlett Jay Engel Sebastien Gilbert Jeremy Parfitt Harman Sekhon Doris M. Rassl Robert C. Rintoul Carlo Bifulco Raina Tamakawa Walter Urba Nicholas Hayward Henri Timmers Anna Antenucci Francesco Facciolo Gianluca Grazi Mirella Marino Roberta Merola Ronald de Krijger Anne-Paule Gimenez-Roqueplo Alain Piché Simone Chevalier Ginette McKercher Kivanc Birsoy Gene Barnett Cathy Brewer Carol Farver Theresa Naska Nathan A. Pennell Daniel Raymond Cathy Schilero Kathy Smolenski Felicia Williams Carl Morrison Jeffrey A. Borgia Michael J. Liptay Mark Pool Christopher W. Seder Kerstin Junker Larsson Omberg Mikhail Dinkin George Manikhas Domenico Alvaro Maria Consiglia Bragazzi Vincenzo Cardinale Guido Carpino Eugenio Gaudio David Chesla Sandra Cottingham Michael Dubina Fedor Moiseenko Renumathy Dhanasekaran Karl-Friedrich Becker Klaus-Peter Janssen Julia Slotta-Huspenina Mohamed H. Abdel-Rahman Dina Aziz Sue Bell Colleen M. Cebulla Amy Davis Rebecca Duell J. Bradley Elder Joe Hilty Bahavna Kumar James Lang Norman L. Lehman Randy Mandt Phuong Nguyen Robert Pilarski Karan Rai Lynn Schoenfield Kelly Senecal Paul Wakely Paul Hansen Ronald Lechan James Powers Arthur Tischler William E. Grizzle Katherine C. Sexton Alison Kastl Joel Henderson Sima Porten Jens Waldmann Martin Fassnacht Sylvia L. Asa Dirk Schadendorf Marta Couce Markus Graefen Hartwig Huland Guido Sauter Thorsten Schlomm Ronald Simon Pierre Tennstedt Oluwole Olabode Mark Nelson Oliver Bathe Peter R. Carroll June M. Chan Philip Disaia Pat Glenn Robin K. Kelley Charles N. Landen Joanna Phillips Michael Prados Jeffry Simko Karen Smith-McCune Scott VandenBerg Kevin Roggin Ashley Fehrenbach Ady Kendler Suzanne Sifri Ruth Steele Antonio Jimeno Francis Carey Ian Forgie Massimo Mannelli Michael Carney Brenda Hernandez Benito Campos Christel Herold-Mende Christin Jungk Andreas Unterberg Andreas von Deimling Aaron Bossler Joseph Galbraith Laura Jacobus Michael Knudson Tina Knutson Deqin Ma Mohammed Milhem Rita Sigmund Rashna Madan Howard G. Rosenthal Clement Adebamowo Sally N. Adebamowo Alex Boussioutas David Beer Thomas Giordano Anne-Marie Mes-Masson Fred Saad Therese Bocklage Lisa Landrum Robert Mannel Kathleen Moore Katherine Moxley Russel Postier Joan Walker Rosemary Zuna Michael Feldman Federico Valdivieso Rajiv Dhir James Luketich Edna M. Mora Pinero Mario Quintero-Aguilo Carlos Gilberto Carlotti Jose Sebastião Dos Santos Rafael Kemp Ajith Sankarankuty Daniela Tirapelli James Catto Kathy Agnew Elizabeth Swisher Jenette Creaney Bruce Robinson Carl Simon Shelley Eryn M. Godwin Sara Kendall Cassaundra Shipman Carol Bradford Thomas Carey Andrea Haddad Jeffey Moyer Lisa Peterson Mark Prince Laura Rozek Gregory Wolf Rayleen Bowman Kwun M. Fong Ian Yang Robert Korst J. Leigh Fantacone-Campbell Jeffrey A. Hooke Albert J. Kovatich Craig D. Shriver John DiPersio Bettina Drake Ramaswamy Govindan Sharon Heath Timothy Ley Brian Van Tine Peter Westervelt Mark A. Rubin Jung Il Lee Natália D. Aredes Armaz Mariamidze SAIC-F-Frederick, Inc Leidos Biomedical Research, Inc. Ricketts C.J. De Cubas A.A. Fan H. Smith C.C. Lang M. Reznik E. Bowlby R. Gibb E.A. Akbani R. Beroukhim R. Bottaro D.P. Choueiri T.K. Gibbs R.A. Godwin A.K. Haake S. Hakimi A.A. Henske E.P. Hsieh J.J. Ho T.H. Kanchi R.S. Krishnan B. Kwaitkowski D.J. Lui W. Merino M.J. Mills G.B. Myers J. Nickerson M.L. Reuter V.E. Schmidt L.S. Shelley C.S. Shen H. Shuch B. Signoretti S. Srinivasan R. Tamboli P. Thomas G. Vincent B.G. Vocke C.D. Wheeler D.A. Yang L. Kim W.T. Robertson A.G. Caesar-Johnson S.J. Demchok J.A. Felau I. Kasapi M. Ferguson M.L. Hutter C.M. Sofia H.J. Tarnuzzer R. Wang Z. Zenklusen J.C. Zhang J.J. Chudamani S. Liu J. Lolla L. Naresh R. Pihl T. Sun Q. Wan Y. Wu Y. Cho J. DeFreitas T. Frazer S. Gehlenborg N. Getz G. Heiman D.I. Kim J. Lawrence M.S. Lin P. Meier S. Noble M.S. Saksena G. Voet D. Zhang H. Bernard B. Chambwe N. Dhankani V. Knijnenburg T. Kramer R. Leinonen K. Liu Y. Miller M. Reynolds S. Shmulevich I. Thorsson V. Zhang W. Broom B.M. Hegde A.M. Ju Z. Korkut A. Li J. Liang H. Ling S. Liu W. Lu Y. Ng K.-S. Rao A. Ryan M. Wang J. Weinstein J.N. Zhang J. Abeshouse A. Armenia J. Chakravarty D. Chatila W.K. de Bruijn I. Gao J. Gross B.E. Heins Z.J. Kundra R. La K. Ladanyi M. Luna A. Nissan M.G. Ochoa A. Phillips S.M. Sanchez-Vega F. Sander C. Schultz N. Sheridan R. Sumer S.O. Sun Y. Taylor B.S. Anur P. Peto M. Spellman P.T. Benz C. Stuart J.M. Wong C.K. Yau C. Hayes D.N. Parker J.S. Wilkerson M.D. Ally A. Balasundaram M. Brooks D. Carlsen R. Chuah E. Dhalla N. Holt R. Jones S.J.M. Kasaian K. Lee D. Ma Y. Marra M.A. Mayo M. Moore R.A. Mungall A.J. Mungall K. Sadeghi S. Schein J.E. Sipahimalani P. Tam A. Thiessen N. Tse K. Wong T. Berger A.C. Cherniack A.D. Cibulskis C. Gabriel S.B. Gao G.F. Ha G. Meyerson M. Schumacher S.E. Shih J. Kucherlapati M.H. Kucherlapati R.S. Baylin S. Cope L. Danilova L. Bootwalla M.S. Lai P.H. Maglinte D.T. Van Den Berg D.J. Weisenberger D.J. Auman J.T. Balu S. Bodenheimer T. Fan C. Hoadley K.A. Hoyle A.P. Jefferys S.R. Jones C.D. Meng S. Mieczkowski P.A. Mose L.E. Perou A.H. Perou C.M. Roach J. Shi Y. Simons J.V. Skelly T. Soloway M.G. Tan D. Veluvolu U. Hinoue T. Laird P.W. Zhou W. Bellair M. Chang K. Covington K. Creighton C.J. Dinh H. Doddapaneni H. Donehower L.A. Drummond J. Glenn R. Hale W. Han Y. Hu J. Korchina V. Lee S. Lewis L. Li W. Liu X. Morgan M. Morton D. Muzny D. Santibanez J. Sheth M. Shinbrot E. Wang L. Wang M. Xi L. Zhao F. Hess J. Appelbaum E.L. Bailey M. Cordes M.G. Ding L. Fronick C.C. Fulton L.A. Fulton R.S. Kandoth C. Mardis E.R. McLellan M.D. Miller C.A. Schmidt H.K. Wilson R.K. Crain D. Curley E. Gardner J. Lau K. Mallery D. Morris S. Paulauskis J. Penny R. Shelton C. Shelton T. Sherman M. Thompson E. Yena P. Bowen J. Gastier-Foster J.M. Gerken M. Leraas K.M. Lichtenberg T.M. Ramirez N.C. Wise L. Zmuda E. Corcoran N. Costello T. Hovens C. Carvalho A.L. de Carvalho A.C. Fregnani J.H. Longatto-Filho A. Reis R.M. Scapulatempo-Neto C. Silveira H.C.S. Vidal D.O. Burnette A. Eschbacher J. Hermes B. Noss A. Singh R. Anderson M.L. Castro P.D. Ittmann M. Huntsman D. Kohl B. Le X. Thorp R. Andry C. Duffy E.R. Lyadov V. Paklina O. Setdikova G. Shabunin A. Tavobilov M. McPherson C. Warnick R. Berkowitz R. Cramer D. Feltmate C. Horowitz N. Kibel A. Muto M. Raut C.P. Malykh A. Barnholtz-Sloan J.S. Barrett W. Devine K. Fulop J. Ostrom Q.T. Shimmel K. Wolinsky Y. Sloan A.E. De Rose A. Giuliante F. Goodman M. Karlan B.Y. Hagedorn C.H. Eckman J. Harr J. Tucker K. Zach L.A. Deyarmin B. Hu H. Kvecher L. Larson C. Mural R.J. Somiari S. Vicha A. Zelinka T. Bennett J. Iacocca M. Rabeno B. Swanson P. Latour M. Lacombe L. Tetu B. Bergeron A. McGraw M. Staugaitis S.M. Chabot J. Hibshoosh H. Sepulveda A. Su T. Wang T. Potapova O. Voronina O. Desjardins L. Mariani O. Roman-Roman S. Sastre X. Stern M.-H. Cheng F. Berchuck A. Bigner D. Lipp E. Marks J. McCall S. McLendon R. Secord A. Sharp A. Behera M. Brat D.J. Chen A. Delman K. Force S. Khuri F. Magliocca K. Maithel S. Olson J.J. Owonikoko T. Pickens A. Ramalingam S. Shin D.M. Sica G. Van Meir E.G. Eijckenboom W. Gillis A. Korpershoek E. Looijenga L. Oosterhuis W. Stoop H. van Kessel K.E. Zwarthoff E.C. Calatozzolo C. Cuppini L. Cuzzubbo S. DiMeco F. Finocchiaro G. Mattei L. Perin A. Pollo B. Chen C. Houck J. Lohavanichbutr P. Hartmann A. Stoehr C. Stoehr R. Taubert H. Wach S. Wullich B. Kycler W. Murawa D. Wiznerowicz M. Chung K. Edenfield W.J. Martin J. Baudin E. Bubley G. Bueno R. De Rienzo A. Richards W.G. Kalkanis S. Mikkelsen T. Noushmehr H. Scarpace L. Girard N. Aymerich M. Campo E. Gine E. Guillermo A.L. Van Bang N. Hanh P.T. Phu B.D. Tang Y. Colman H. Evason K. Dottino P.R. Martignetti J.A. Gabra H. Juhl H. Akeredolu T. Stepa S. Hoon D. Ahn K. Kang K.J. Beuschlein F. Breggia A. Birrer M. Bell D. Borad M. Bryce A.H. Castle E. Chandan V. Cheville J. Copland J.A. Farnell M. Flotte T. Giama N. Kendrick M. Kocher J.-P. Kopp K. Moser C. Nagorney D. O'Brien D. O'Neill B.P. Patel T. Petersen G. Que F. Rivera M. Roberts L. Smallridge R. Smyrk T. Stanton M. Thompson R.H. Torbenson M. Yang J.D. Zhang L. Brimo F. Ajani J.A. Gonzalez A.M.A. Behrens C. Bondaruk J. Broaddus R. Czerniak B. Esmaeli B. Fujimoto J. Gershenwald J. Guo C. Lazar A.J. Logothetis C. Meric-Bernstam F. Moran C. Ramondetta L. Rice D. Sood A. Thompson T. Troncoso P. Tsao A. Wistuba I. Carter C. Haydu L. Hersey P. Jakrot V. Kakavand H. Kefford R. Lee K. Long G. Mann G. Quinn M. Saw R. Scolyer R. Shannon K. Spillane A. Stretch O. Synott M. Thompson J. Wilmott J. Al-Ahmadie H. Chan T.A. Ghossein R. Gopalan A. Levine D.A. Singer S. Singh B. Tien N.V. Broudy T. Mirsaidi C. Nair P. Drwiega P. Miller J. Smith J. Zaren H. Park J.-W. Hung N.P. Kebebew E. Linehan W.M. Metwalli A.R. Pacak K. Pinto P.A. Schiffman M. Wentzensen N. Worrell R. Yang H. Moncrieff M. Goparaju C. Melamed J. Pass H. Botnariuc N. Caraman I. Cernat M. Chemencedji I. Clipca A. Doruc S. Gorincioi G. Mura S. Pirtac M. Stancul I. Tcaciuc D. Albert M. Alexopoulou I. Arnaout A. Bartlett J. Engel J. Gilbert S. Parfitt J. Sekhon H. Rassl D.M. Rintoul R.C. Bifulco C. Tamakawa R. Urba W. Hayward N. Timmers H. Antenucci A. Facciolo F. Grazi G. Marino M. Merola R. de Krijger R. Gimenez-Roqueplo A.-P. Piche A. Chevalier S. McKercher G. Birsoy K. Barnett G. Brewer C. Farver C. Naska T. Pennell N.A. Raymond D. Schilero C. Smolenski K. Williams F. Morrison C. Borgia J.A. Liptay M.J. Pool M. Seder C.W. Junker K. Omberg L. Dinkin M. Manikhas G. Alvaro D. Bragazzi M.C. Cardinale V. Carpino G. Gaudio E. Chesla D. Cottingham S. Dubina M. Moiseenko F. Dhanasekaran R. Becker K.-F. Janssen K.-P. Slotta-Huspenina J. Abdel-Rahman M.H. Aziz D. Bell S. Cebulla C.M. Davis A. Duell R. Elder J.B. Hilty J. Kumar B. Lang J. Lehman N.L. Mandt R. Nguyen P. Pilarski R. Rai K. Schoenfield L. Senecal K. Wakely P. Hansen P. Lechan R. Powers J. Tischler A. Grizzle W.E. Sexton K.C. Kastl A. Henderson J. Porten S. Waldmann J. Fassnacht M. Asa S.L. Schadendorf D. Couce M. Graefen M. Huland H. Sauter G. Schlomm T. Simon R. Tennstedt P. Olabode O. Nelson M. Bathe O. Carroll P.R. Chan J.M. Disaia P. Glenn P. Kelley R.K. Landen C.N. Phillips J. Prados M. Simko J. Smith-McCune K. VandenBerg S. Roggin K. Fehrenbach A. Kendler A. Sifri S. Steele R. Jimeno A. Carey F. Forgie I. Mannelli M. Carney M. Hernandez B. Campos B. Herold-Mende C. Jungk C. Unterberg A. von Deimling A. Bossler A. Galbraith J. Jacobus L. Knudson M. Knutson T. Ma D. Milhem M. Sigmund R. Madan R. Rosenthal H.G. Adebamowo C. Adebamowo S.N. Boussioutas A. Beer D. Giordano T. Mes-Masson A.-M. Saad F. Bocklage T. Landrum L. Mannel R. Moore K. Moxley K. Postier R. Walker J. Zuna R. Feldman M. Valdivieso F. Dhir R. Luketich J. Pinero E.M.M. Quintero-Aguilo M. Carlotti C.G. Dos Santos J.S. Kemp R. Sankarankuty A. Tirapelli D. Catto J. Agnew K. Swisher E. Creaney J. Robinson B. Godwin E.M. Kendall S. Shipman C. Bradford C. Carey T. Haddad A. Moyer J. Peterson L. Prince M. Rozek L. Wolf G. Bowman R. Fong K.M. Yang I. Korst R. Rathmell W.K. Fantacone-Campbell J.L. Hooke J.A. Kovatich A.J. Shriver C.D. DiPersio J. Drake B. Govindan R. Heath S. Ley T. Van Tine B. Westervelt P. Rubin M.A. Lee J.I. Aredes N.D. Mariamidze A.
Source :
Ricketts, Christopher J; De Cubas, Aguirre A; Fan, Huihui; Smith, Christof C; Lang, Martin; Reznik, Ed; Bowlby, Reanne; Gibb, Ewan A; Akbani, Rehan; Beroukhim, Rameen; Bottaro, Donald P; Choueiri, Toni K; Gibbs, Richard A; Godwin, Andrew K; Haake, Scott; Hakimi, A Ari; Henske, Elizabeth P; Hsieh, James J; Ho, Thai H; Kanchi, Rupa S; ... (2018). The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell reports, 23(12), p. 3698. Cell Press 10.1016/j.celrep.2018.06.032 , 326.e5, Cell Reports, Vol 23, Iss 1, Pp 313-326.e5 (2018), Cell Reports, 23(1), 313. Cell Press, Ricketts, Christopher J; De Cubas, Aguirre A; Fan, Huihui; Smith, Christof C; Lang, Martin; Reznik, Ed; Bowlby, Reanne; Gibb, Ewan A; Akbani, Rehan; Beroukhim, Rameen; Bottaro, Donald P; Choueiri, Toni K; Gibbs, Richard A; Godwin, Andrew K; Haake, Scott; Hakimi, A Ari; Henske, Elizabeth P; Hsieh, James J; Ho, Thai H; Kanchi, Rupa S; ... (2018). The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell reports, 23(1), 313-326.e5. Cell Press 10.1016/j.celrep.2018.03.075 , Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Cell reports
Publication Year :
2017
Abstract
SUMMARY Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival.<br />Graphical abstract In Brief Ricketts et al. find distinctive features of each RCC subtype, providing the foundation for development of subtypespecific therapeutic and management strategies. Somatic alteration of BAP1, PBRM1, and metabolic pathways correlates with subtype-specific decreased survival, while CDKN2A alteration, DNA hypermethylation, and Th2 immune signature correlate with decreased survival within all subtypes.
Details
ISSN :
22111247
Volume :
23
Issue :
1
Database :
OpenAIRE
Journal :
Cell reports
Accession number :
edsair.doi.dedup.....f6370f62585eeabb2024775cbe313be6