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Arterial Hypertension and Plasma Glucose Modulate the Vasoactive Effects of Nitroso-Sulfide Coupled Signaling in Human Intrarenal Arteries
- Source :
- Molecules, Molecules, Vol 25, Iss 2886, p 2886 (2020), Volume 25, Issue 12
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- We have investigated the vasoactive effects of the coupled nitro-sulfide signaling pathway in lobar arteries (LAs) isolated from the nephrectomized kidneys of cancer patients: normotensive patients (NT) and patients with arterial hypertension (AH). LAs of patients with AH revealed endothelial dysfunction, which was associated with an increased response to the exogenous NO donor, nitrosoglutathione (GSNO). The interaction of GSNO with the H2S donor triggered a specific vasoactive response. Unlike in normotensive patients, in patients with AH, the starting and returning of the vasorelaxation induced by the end-products of the H2S-GSNO interaction (S/GSNO) was significantly faster, however, without the potentiation of the maximum. Moreover, increasing glycemia shortened the time required to reach 50% of the maximum vasorelaxant response induced by S/GSNO products so modulating their final effect. Moreover, we found out that, unlike K+ channel activation, cGMP pathway and HNO as probable mediator could be involved in mechanisms of S/GSNO action. For the first time, we demonstrated the expression of genes coding H2S-producing enzymes in perivascular adipose tissue and we showed the localization of these enzymes in LAs of normotensive patients and in patients with AH. Our study confirmed that the heterogeneity of specific nitroso-sulfide vasoactive signaling exists depending on the occurrence of hypertension associated with increased plasma glucose level. Endogenous H2S and the end-products of the H2S-GSNO interaction could represent prospective pharmacological targets to modulate the vasoactive properties of human intrarenal arteries.
- Subjects :
- Blood Glucose
Male
hydrogen sulfide
Pharmaceutical Science
Adipose tissue
Endogeny
01 natural sciences
Analytical Chemistry
S-Nitrosoglutathione
chemistry.chemical_compound
Renal Artery
Drug Discovery
S-nitrosoglutathione
Endothelial dysfunction
chemistry.chemical_classification
0303 health sciences
normotensive
Long-term potentiation
Middle Aged
Glutathione
Vasodilation
Protein Transport
human lobar artery
Chemistry (miscellaneous)
Hypertension
Molecular Medicine
Female
Signal transduction
Signal Transduction
Serotonin
arterial hypertension
nitroso-sulfide signaling
medicine.medical_specialty
Cystathionine beta-Synthase
Sulfides
Nitric Oxide
010402 general chemistry
Gene Expression Regulation, Enzymologic
Article
CBS
lcsh:QD241-441
03 medical and health sciences
Thoracic Arteries
Mediator
lcsh:Organic chemistry
Internal medicine
medicine
Animals
Humans
immunofluorescence
Physical and Theoretical Chemistry
030304 developmental biology
CTH gene expression
Organic Chemistry
Cystathionine gamma-Lyase
medicine.disease
Rats
0104 chemical sciences
Enzyme
Endocrinology
chemistry
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....f6317408836ebb30b0ee46da145500ea