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Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders
- Source :
- Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-16 (2018), Lipids in Health and Disease
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background In recent decade, Hyperlipidemia related disorders like obesity, hypercholesterolemia and diabetes are considered as the leading killers for mankind. Fundamental nexus between nutrition and health diverting the consumers focus towards plant based natural products as a remedy against various metabolic syndrome. Considering this, present study was conducted to explicate the role of black tea polyphenols such as Theaflavins and thearubigins therapeutic potential to tackle targeted maladies especially oxidative stress related disorders like hypercholesterolemia and diabetes. Methods The mandate of current investigation was to explore the hypoglycemic and hypocholestrolemic perspective of isolated theaflavin and thearubigins through a model feeding trial. For the purpose, theaflavin & thearubigins were isolated from black tea through solvent partition method and utilize to form three types of nutraceutical drinks (theaflavin, thearubigins & theaflavin + thearubigins based) alongside control to be further utilized in bioefficacy trial. In bioefficacy trial, three types of independent studies were design on the bases of diet by involving 20 male wistar rats in each study (5 for each group). In study I, normal diet was administrated while, in study II & III high cholesterol and high sucrose diet was given, respectively along with prepared nutraceutical drinks to synchronize their therapeutic effect for a period of 56 days. At the termination of trial, Feed & drink intakes, body weight, total cholesterol, LDL, HDL, triglycerides, glucose and insulin levels were measured. Results The results indicated reduction in cholesterol, LDL and triglycerides levels of experimental rats in all studies with significant increase in HDL. In this context, theaflavin based drink imparted maximum reduction in cholesterol (3.75, 11.03 & 10.39%), LDL (3.84, 14.25& 10.84%) & triglycerides (2.99, 8.54 & 6.65%) in respective studies compared to thearubigins and theaflavin + thearubigins based drinks. However, theaflavin+ thearubigins based drink caused highest glucose decline and maximum insulin increase in all studies as compared to other nutraceutical drinks. The reported value for the insulin increase were 13.02 ± 1.02 & 14.55 ± 1.13, 10.09 ± 0.15 & 11.59 ± 0.86 for Hyperglycemic and Hypocholestrolemic rats respectively compared to control (7.84 ± 0.45 & 9.10 ± 0.41) for study I and II. Conclusions In the nutshell, theaflavin and thearubigins based dietary interventions are helpful to alleviate the hypercholestrolemia and hyperglycemia and should be promoted as parallel therapy to combat these disorders.
- Subjects :
- 0301 basic medicine
Male
Normal diet
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Context (language use)
Hyperlipidemias
Dietary interventions
High cholesterol
Catechin
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
Endocrinology
Nutraceutical
Hyperlipidemia
Medicine
Animals
Food science
Theaflavin
Rats, Wistar
lcsh:RC620-627
Flavonoids
030109 nutrition & dietetics
Tea
Cholesterol
business.industry
Research
Biochemistry (medical)
Polyphenols
04 agricultural and veterinary sciences
medicine.disease
040401 food science
Rats
lcsh:Nutritional diseases. Deficiency diseases
chemistry
Thearubigins
Metabolic syndrome
business
Subjects
Details
- Language :
- English
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Lipids in Health and Disease
- Accession number :
- edsair.doi.dedup.....f62e2319ec9938b01102a4d66a15274a